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S. Zhu y col. Org. Lett. (South China University of Technology, Guangzhou))

Iron-catalyzed Benzannulation Reactions of 2‑Alkylbenzaldehydes and Alkynes Leading to Naphthalene Derivatives. 5% mol 1-2 h, 60 ºC. An efficient and practical method for the synthesis of naphthalene derivatives via Fe(III)-catalyzed benzannulation of 2-(2-oxoethyl)-benzaldehydes

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S. Zhu y col. Org. Lett. (South China University of Technology, Guangzhou))

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  1. Iron-catalyzed Benzannulation Reactionsof 2‑Alkylbenzaldehydes and AlkynesLeading to Naphthalene Derivatives 5% mol 1-2 h, 60 ºC An efficient and practical method for the synthesis of naphthalene derivatives via Fe(III)-catalyzed benzannulation of 2-(2-oxoethyl)-benzaldehydes and alkynes has been developed. The system holds the advantages of cheap catalysts, wide substrate scope, and mild reaction conditions. S. Zhu y col. Org. Lett. (South China University of Technology, Guangzhou))

  2. Trabajo previo Este trabajo

  3. No reacción sin catalizador o con catálisis ácida (H+) Catalizadores: AgSbF6, ZnCl2, FeCl3 H, Ph, Alquilo, Br H,OMe, F,CF3 XC6H4, Alquilo 60-99% X: MeO, Me, Cl, H,(CF3)2

  4. Mecanismo propuesto

  5. ¿Síntesis de heterociclos?

  6. Synthesis of Pinacol Arylboronates from Aromatic Amines: A Metal-Free Transformation F. Mo, J. Wang y col. J. Org. Chem. (Beijing National Laboratory of Molecular Sciences)

  7. Rutas a ácidos arilborónicos y arilboronatos

  8. Comparación con otros métodos BPO • Ausencia de metal • Arilaminas abundantes y no caras • Tolerancia de grupos funcionales • Condiciones suaves

  9. Productos aromáticos

  10. Boración-acoplamiento C-C secuenciales Het-Bpin inestable en gel de sílice Escalable a cantidades de multigramo

  11. Mecanismo propuesto

  12. Synthesis of Imidazo[1,2-a]pyridines: “Water-Mediated” Hydroamination and Silver-Catalyzed Aminooxygenation S. Adimurthy y col. J. Org. Chem. (Central Salt and Marine Chemicals Research Institute, Gujarat)

  13. ansiolítico ansiolítico sedante VIH Fallo cardiaco Osteoporosis

  14. Hidroaminación

  15. Deuteración

  16. Aminooxigenación

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