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ESSENTIAL THROMBOCYTHEMIA AND PREGNANCY PRELIMINARY REPORT OF THE PREGNANCY COMMITTEE OF THE REGISTRO ITALIANO TROMBOCITEMIE (RIT) L Melillo 1 , A Tieghi 2 , A.Candoni 3 , R Ciancia 4 , V Martinelli 4 , R Latagliata 5 , G Specchia 6 , PR Scalzulli 1 , R Fanci 7 , G Comitini 2 ,
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ESSENTIAL THROMBOCYTHEMIA AND PREGNANCY PRELIMINARY REPORT OF THE PREGNANCY COMMITTEE OF THE REGISTRO ITALIANO TROMBOCITEMIE (RIT) L Melillo1, A Tieghi 2, A.Candoni 3, R Ciancia4, V Martinelli4, R Latagliata5, G Specchia6, PR Scalzulli1, R Fanci7, G Comitini2, N Cascavilla1 and L Gugliotta 2 on behalf of the Registro Italiano Trombocitemie (RIT ) 1Hematology Unit S. Giovanni Rotondo, 2Hematology Unit Reggio Emilia, 3Hematology Unit Udine, 4Hematology University of Napoli, 5Hematology University of Roma1, 6Hematology University of Bari, 7Hematology University of Firenze, Italy. This study is supported by a Ministero Istruzione, Università e Ricerca grant ( Grant RC0606EM71) Patients characteristics Legend – GA gestational age; SA spontaneous abortion; VA voluntary abortion; A&W alive and healthy; SB still birth; FT term; IUD intrauterine death; IUGR intrauterine growth retard § Pregnancy occurred before ET diagnosis * Pregnancy started during ET treatment Conclusions • These data confirm that fetal morbidity and mortality is not negligible in ET • Cytoreductive therapy with AlphaIFN seems potentially able to protect against fetal losses • Although normal pregnancies have been observed in patients who conceived during cytotoxic treatment, effective forms of contraception throughout treatment is still strongly recommended • Optimal management of pregnancy in ET patients is still poorly defined, and there are no established protocols. Recommendations for ET in pregnancy, based on current knowledge of ET and the management of inherited thrombophilia and the Antiphospholipid Syndrome in pregnancy, have been proposed ( Harrison,BJH 2005) • The epidemiological, clinical and biological data on pregnancy in ET obtained by the partecipating Centres are now object of a prospective study by the RIT, a GIMEMA projects which records the ET patients diagnosed in Italy since January 2004.