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Three-component model of anxiety

Three-component model of anxiety

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Three-component model of anxiety

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  1. Three-component model of anxiety Anxiety Disorders • Generalized anxiety disorder • Panic attacks • Phobias • Post-traumatic stress disorder • Obsessive-compulive disorder

  2. Neurotransmitters responsible for anxiety response: GABA Norepinephrine Corticotropin-releasing factor

  3. Early Experience and Stress

  4. Early Experience and Stress

  5. Dose-dependent effects of CNS depressants on levels of consciousness

  6. Treating anxiety disorders Anxiolytics – drugs that reduce anxiety • Barbiturates (nembutal – pentobarbital) • Benzodiazepines (valium – diazepam, rohypnol) • Alcohol

  7. Barbiturates • Acute effects • Relieves anxiety • Produces sleep/anesthesia • Loss of judgment etc. • High when injected • Chronic effects • Increase liver enzymes • Rebound excitability effect similar to alcohol

  8. 17.9 Margin of safety

  9. Benzodiazepine • Acute effects • Relieves anxiety • Less loss of judgment etc. • Muscle relaxant • Chronic effects • Do NOT increase liver enzymes

  10. Drug effects on locus coeruleus cell firing