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Cardiac Tissue Matrix. Katelyn Pate. Statistics. Heart disease and stroke are the 1 st and 3 rd leading cause of death in the U.S. They account for 40% of all deaths, more than all cancer combined Congenital heart defects occur in nearly 14 of every 1000 newborn children

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Presentation Transcript
statistics
Statistics

Heart disease and stroke are the 1st and 3rd leading cause of death in the U.S.

They account for 40% of all deaths, more than all cancer combined

Congenital heart defects occur in nearly 14 of every 1000 newborn children

Most common congenital defect and leading cause of death in first year of life

why is this important
Why is this Important?
  • Cardiac tissue has very low regenerative capabilities
  • Tissue engineering can be used to:
    • Reconstruct malformed hearts in children
    • Regenerate failing hearts in adults
background
Background
  • 3 Approaches
    • Administration of liquid-phase cell suspensions
    • Hydrogel cell delivery via catheters
    • Contractile cardiac tissue engineered patch
injection of cell s uspensions
Injection of Cell Suspensions

Advantages

Disadvantages

Very convenient

Low engraftment and cell survival

hydrogel c ell delivery
Hydrogel Cell Delivery

Advantages

Disadvantages

Improved cell retention over injection via a syringe

Offers customization using growth factors

Still low engraftment and cell survival

cardiac tissue engineered patch
Cardiac Tissue Engineered Patch

Advantages

Disadvantages

Deliver cells with immediate function and capacity for vascular and electromechanical integration with the heart

Difficult to create a scaffold that displays functional and morphological properties of native heart muscles