Vyfat Capsules (Generic Orlistat Capsules)

1. Vyfat Capsules (Generic Orlistat Capsules) © Clearsky Pharmacy ( www.clearskypharmacy.biz )

2. Vyfat Capsules (Generic Orlistat Capsules) Vyfat Capsules (Generic Orlistat 120 mg Capsules) are used for obesity management including weight loss and weight maintenance when used along with a reduced-calorie diet. Vyfat is also indicated to reduce the risk for weight regain after prior weight loss. Vyfat 120 mg capsules are used for obese patients with an initial body mass index (BMI) of 30 kg/m2 or more than 27 kg/m2 in the presence of other risk factors (e.g., hypertension, diabetes, dyslipidemia). Vyfat 60 mg Capsules are used for weight loss in overweight adults, 18 years and older, when used along with a reduced- calorie and low-fat diet. © Clearsky Pharmacy ( www.clearskypharmacy.biz )

3. Vyfat Capsules (Generic Orlistat Capsules) Active Ingredient The active ingredient contained in Vyfat capsules is Orlistat. Each capsule of Vyfat contains either 60 mg or 120 mg of Orlistat. © Clearsky Pharmacy ( www.clearskypharmacy.biz )

4. Vyfat Capsules (Generic Orlistat Capsules) Chemical Structure The structure of Orlistat is given below: © Clearsky Pharmacy ( www.clearskypharmacy.biz )

5. Vyfat Capsules (Generic Orlistat Capsules) Vyfat Capsules are manufactured by Intas Pharmaceuticals Limited, India in the strengths of 60 mg and 120 mg. ( Website: https://www.intaspharma.com/ ) URL: https://www.clearskypharmacy.biz/generic-xenical-vyfat-by-intas.html © Clearsky Pharmacy ( www.clearskypharmacy.biz )

6. Vyfat Capsules (Generic Orlistat Capsules) Orlistat Capsules– Brand Names Orlistat capsules are available under various drug trade names that include Xenical, Alli, Beacita, Orlos, Vyfat, Orligal, Cobese, Obelit, Obitrol, Orlica, Orlitrox, Reeshap and Zerofat. © Clearsky Pharmacy ( www.clearskypharmacy.biz )

7. Vyfat Capsules (Generic Orlistat Capsules) Uses of Vyfat Capsules Vyfat capsules (Generic Orlistat capsules) are used with a doctor- approved exercise, behavior change, and reduced-calorie diet program to help you lose weight. It is used by certain overweight people, such as those who are obese or have weight-related medical problems. Taking Orlistat capsules can also help keep you from gaining back weight you have lost. Losing weight and keeping it off can lessen the many health risks that come with obesity, including heart disease, diabetes, high blood pressure, and a shorter life. URL: https://www.clearskypharmacy.biz/generic-xenical-vyfat-by-intas.html © Clearsky Pharmacy ( www.clearskypharmacy.biz )

8. Vyfat Capsules (Generic Orlistat Capsules) Uses of Vyfat Capsules Dietary fats need to be broken down into smaller pieces before the body can absorb them. Orlistat works by blocking the enzyme that breaks down fats in your diet, and thus keeps your intestines from absorbing some of the fats from the food that you eat. This undigested fat then passes out of your body in your bowel movement. Orlistat does not block the absorption of calories from sugar and other non-fat foods, so you still need to restrict your total intake of calories. It is also used in overweight people who may also have diabetes, high blood pressure, high cholesterol, or heart disease. URL: https://www.clearskypharmacy.biz/generic-xenical-vyfat-by-intas.html © Clearsky Pharmacy ( www.clearskypharmacy.biz )

9. Vyfat Capsules (Generic Orlistat Capsules) Vyfat 120 mg Capsules Dosage The dosage of Vyfat 120mg Capsules (Generic Orlistat 120 mg Capsules) is given below: One 120-mg Vyfat capsule three times a day with each main meal containing fat (during or up to 1 hour after the meal). Advise patients to take a nutritionally balanced, reduced-calorie diet that contains approximately 30% of calories from fat. Distribute the daily intake of fat, carbohydrate, and protein over three main meals. Advise patients to take a multivitamin containing fat-soluble vitamins to ensure adequate nutrition. URL: https://www.clearskypharmacy.biz/generic-xenical-vyfat-by-intas.html © Clearsky Pharmacy ( www.clearskypharmacy.biz )

10. Vyfat Capsules (Generic Orlistat Capsules) Vyfat 120 mg Capsules Dosage The dosage of Vyfat 120mg Capsules (Generic Orlistat 120 mg Capsules) is given below: Take the vitamin supplement at least 2 hours before or after the administration of Vyfat 120mg capsules , such as at bedtime. For patients being administered both Vyfat Capsules and Cyclosporine therapy, administer Cyclosporine three hours after Vyfat capsules. For patients being administered both Vyfat Capsules and Levothyroxine therapy, administer Levothyroxine and Vyfat capsules at least four hours apart. URL: https://www.clearskypharmacy.biz/generic-xenical-vyfat-by-intas.html © Clearsky Pharmacy ( www.clearskypharmacy.biz )

11. Vyfat Capsules (Generic Orlistat Capsules) Contraindications Vyfat capsules are contraindicated in persons with a hypersensitivity (allergy) to Orlistat or any of the other ingredients of this medicine. Vyfat capsules are also contraindicated in patients who are pregnant. Weight loss offers no potential benefit to a pregnant woman and may result in fetal harm. A minimum weight gain, and no weight loss, is currently recommended for all pregnant women, including those who are already overweight or obese, due to the obligatory weight gain that occurs in maternal tissues during pregnancy. Generic Orlistat Capsules (Vyfat) are also contraindicated in patients with with chronic malabsorption syndrome and patients with cholestasis. URL: https://www.clearskypharmacy.biz/generic-xenical-vyfat-by-intas.html © Clearsky Pharmacy ( www.clearskypharmacy.biz )

12. Vyfat Capsules (Generic Orlistat Capsules) Storage Instructions Vyfat Capsules (Generic Orlistat Capsules) have to be stored at controlled room temperature i.e. from 20°C to 25°C (68°F to 77°F) with excursions permitted between 15° to 30°C (59° to 86°F). Keep this as well as all other medicines away from children and pets. URL: https://www.clearskypharmacy.biz/generic-xenical-vyfat-by-intas.html © Clearsky Pharmacy ( www.clearskypharmacy.biz )

13. Vyfat Capsules (Generic Orlistat Capsules) Warnings Orlistat capsules (Vyfat) may interact with concomitant drugs including Cyclosporine, Levothyroxine, Warfarin, Amiodarone, Antiepileptic drugs, and antiretroviral medicines. Orlistat capsules (Vyfat) can decrease cyclosporine exposure. Vyfat capsules and Cyclosporine should not be simultaneously co-administered. Patients should be strongly encouraged to take a multivitamin supplement that contains fat-soluble vitamins to ensure adequate nutrition because Vyfat has been shown to reduce the absorption of some fat-soluble vitamins and beta-carotene. Rare cases of severe liver injury with hepatocellular necrosis or acute hepatic failure have been reported, with some of these cases resulting in liver transplant or death. URL: https://www.clearskypharmacy.biz/generic-xenical-vyfat-by-intas.html © Clearsky Pharmacy ( www.clearskypharmacy.biz )

14. Vyfat Capsules (Generic Orlistat Capsules) Warnings Patients may develop increased levels of urinary oxalate following treatment with Orlistat Capsules (Vyfat). Monitor renal function in patients at risk for renal insufficiency. Substantial weight loss can increase the risk of cholelithiasis. Exclude organic causes of obesity (e.g., hypothyroidism) before prescribing Orlistat capsules (Vyfat). Patients must be advised to strictly adhere to dietary guidelines. Gastrointestinal events may increase when Orlistat capsules (Vyfat) is taken with a diet high in fat (more than 30% total daily calories from fat). URL: https://www.clearskypharmacy.biz/generic-xenical-vyfat-by-intas.html © Clearsky Pharmacy ( www.clearskypharmacy.biz )

15. Vyfat Capsules (Generic Orlistat Capsules) Side Effects Most common Orlistat Capsules (Vyfat) side effects with an incidence rate of 5% or greater and at least twice that of placebo include oily spotting, flatus with discharge, fecal urgency, fatty/oily stool, oily evacuation, increased defecation and fecal incontinence. The incidence of these side effects increase with increasing fat content of the diet. Treatment-emergent GI side effects that occurred commonly among patients treated with Vyfat Capsules were: abdominal pain /discomfort, flatulence, liquid stools, soft stools, rectal pain /discomfort, tooth disorder, gingival disorder. Other side effects observed were: upper respiratory infection, lower respiratory infection; influenza; headache; menstrual irregularity; anxiety; fatigue; urinary tract infection. URL: https://www.clearskypharmacy.biz/generic-xenical-vyfat-by-intas.html © Clearsky Pharmacy ( www.clearskypharmacy.biz )

16. Vyfat Capsules (Generic Orlistat Capsules) Side Effects Unique treatment adverse events observed in obese type 2 diabetic patients were hypoglycaemia (very common) and abdominal distension (common). Weight loss caused by Generic Orlistat Capsules (Vyfat) is accompanied by improved metabolic control in type 2 diabetics which might allow or require reduction in the dose of hypoglycaemic medication. URL: https://www.clearskypharmacy.biz/generic-xenical-vyfat-by-intas.html © Clearsky Pharmacy ( www.clearskypharmacy.biz )

17. Vyfat Capsules (Generic Orlistat Capsules) Overdose Single doses of 800 mg Orlistat capsules and multiple doses of up to 400 mg three times daily for 15 days have been studied in normal weight and obese subjects without significant adverse findings. In addition, doses of 240 mg three times a day have been administered to obese patients for 6 months. The majority of Orlistat Capsules overdose cases received during post-marketing reported either no adverse events or adverse events that are similar to those reported with recommended dose. URL: https://www.clearskypharmacy.biz/generic-xenical-vyfat-by-intas.html © Clearsky Pharmacy ( www.clearskypharmacy.biz )

18. Vyfat Capsules (Generic Orlistat Capsules) Overdose Should a significant overdose of Orlistat (Vyfat Capsules) occur, it is recommended that the patient be observed for 24 hours. Based on human and animal studies, any systemic effects attributable to the lipase-inhibiting properties of Orlistat should be quickly reversible. URL: https://www.clearskypharmacy.biz/generic-xenical-vyfat-by-intas.html © Clearsky Pharmacy ( www.clearskypharmacy.biz )

19. Vyfat Capsules (Generic Orlistat Capsules) Vyfat Capsules During Pregnancy Orlistat (Vyfat capsules) has been classified by the US FDA as Pregnancy Category X. Orlistat (Vyfat Capsules) is contraindicated during pregnancy, because weight loss offers no potential benefit to a pregnant woman and may result in fetal harm. A minimum weight gain, and no weight loss, is currently recommended for all pregnant women, including those who are already overweight or obese, due to the obligatory weight gain that takes place in maternal tissues during pregnancy. No embryotoxicity or teratogenicity was seen in animals that received Orlistat at doses much higher than the recommended human dose. If this drug is used during pregnancy, or if the patient becomes pregnant while taking this drug, the patient should be apprised of the potential hazard of maternal weight loss to the fetus. URL: https://www.clearskypharmacy.biz/generic-xenical-vyfat-by-intas.html © Clearsky Pharmacy ( www.clearskypharmacy.biz )

20. Vyfat Capsules (Generic Orlistat Capsules) For more details on Vyfat Capsules click here Vyfat Capsules (Generic Orlistat Capsules) by Intas Pharmaceuticals Limited, India. URL: https://www.clearskypharmacy.biz/generic-xenical-vyfat-by-intas.html © Clearsky Pharmacy ( www.clearskypharmacy.biz )