A-Ret Gel (Generic Tretinoin Gel)

1. A-Ret Gel (Generic Tretinoin Gel) © Clearsky Pharmacy ( www.clearskypharmacy.biz )

2. A-Ret Gel (Generic Tretinoin Gel) A-Ret Gel (Generic Tretinoin Gel), 0.025%, 0.05%, 0.10%, is used for topical application in the treatment of acne vulgaris. Tretinoin gel is used to treat fine wrinkles, dark spots, or rough skin on the face caused by the damaging rays of the sun. It works by lightening the skin, replacing older skin with newer skin, and slowing down the way the body removes skin cells that may have been harmed by the sun. Tretinoin works best when used within a skin care program that includes protecting the treated skin from the sun. The safety and efficacy of the use of A-Ret Gel in the treatment of other disorders have not been established. A-Ret Gel is manufactured by Akums Drugs & Pharmaceuticals Limited and marketed by A. Menarini India Private Limited. © Clearsky Pharmacy ( www.clearskypharmacy.biz )

3. A-Ret Gel (Generic Tretinoin Gel) Active Ingredient The active ingredient present in A-Ret gel is Tretinoin. Each gram of cream contains 1 mg (0.10% w/w), 0.5 mg (0.05% w/w) or 0.25 mg (0.025% w/w) Tretinoin in in an aqueous gel. © Clearsky Pharmacy ( www.clearskypharmacy.biz )

4. A-Ret Gel (Generic Tretinoin Gel) Chemical Structure The structure of Tretinoin is given below: © Clearsky Pharmacy ( www.clearskypharmacy.biz )

5. A-Ret Gel (Generic Tretinoin Gel) A-Ret Gel is manufactured by Akums Drugs & Pharmaceuticals Limited, India and marketed by A. Menarini India Private Limited in the strengths of 0.10%, 0.05% and 0.025%. The gel is supplied in 20 grams tubes. ( Website: https://www.menariniapac.com/ https://www.menariniapac.com/ ) URL: URL: https://www.clearskypharmacy.biz/a-ret-gel.html https://www.clearskypharmacy.biz/a-ret-gel.html © Clearsky Pharmacy ( www.clearskypharmacy.biz )

6. A-Ret Gel (Generic Tretinoin Gel) Tretinoin Gel – Brand Names Tretinoin Cream/Gel is available under various drug trade names that include Retin-A Cream, Retino-A Cream, Tretin Cream, Nexret Gel, Sotret Gel, A Ret Cream, A-Ret Gel, Airol Cream, Comedolytic Cream, Eudyna Cream, Tretiriv Cream, Treto Gel, Renova Cream, Atralin Cream, Avita Cream, Refissa Cream, Stieva-A Cream, Trewar Cream and Tronin Cream. © Clearsky Pharmacy ( www.clearskypharmacy.biz )

7. A-Ret Gel (Generic Tretinoin Gel) Uses of A-Ret 0.025%, 0.05% and 0.10% Gel A-Ret Gel (Tretinoin 0.025%, 0.05%, 0.1% Gel ) is used to treat acne. It may decrease the number and severity of acne pimples and promote quick healing of pimples that do develop. Tretinoin belongs to a class of medications called retinoids. It works by affecting the growth of skin cells and by keeping skin pores clear. Tretinoin gel is also used to treat fine wrinkles, dark spots, or rough skin on the face caused by the damaging rays of the sun. It works by lightening the skin, replacing older skin with newer skin, and slowing down the way the body removes skin cells that may have been harmed by the sun. Tretinoin works best when used within a skin care program that includes protecting the treated skin from the sun. However, it does not completely or permanently erase these skin problems or greatly improve more obvious changes in the skin, such as deep wrinkles caused by the sun or the natural aging process. © Clearsky Pharmacy ( www.clearskypharmacy.biz )

8. A-Ret Gel (Generic Tretinoin Gel) A-Ret Gel – How Does it Work? Tretinoin gel (A-Ret gel) is highly effective in the treatment of acne, although the exact mode of action of Tretinoin is unknown. Current evidence suggests that this efficacy is due primarily to the ability of tretinoin to modify abnormal follicular keratinization. Comedones form in follicles due to abnormal keratinization and intercellular cohesiveness, with an excess of keratin retained in the follicle. Tretinoin promotes detachment of cornified cells and the enhanced shedding of corneocytes from the follicle. By increasing the mitotic activity of follicular epithelia, Tretinoin also increases the turnover rates of thin, loosely-adherent corneocytes. Through these actions, the comedo contents are extruded and the formation of the microcomedo, the precursor lesion of acne vulgaris, is reduced. © Clearsky Pharmacy ( www.clearskypharmacy.biz )

9. A-Ret Gel (Generic Tretinoin Gel) A-Ret Gel Dosage A-Ret Gel (Generic Tretinoin Gel) is given The dosage of A-Ret Gel below: A-Ret gel should be applied once daily, before bedtime, to the skin where acne lesions appear, using a thin layer to cover the entire affected area. A-Ret gel (Tretinoin 0.025%, 0.05% and 0.10% gel) is not for ophthalmic, oral, or intravaginal use. Tretinoin gel should be kept away from the eyes, the mouth, paranasal creases, and mucous membranes. Application of excessive amounts of the gel will not provide incremental efficacy. URL: URL: https://www.clearskypharmacy.biz/a-ret-gel.html https://www.clearskypharmacy.biz/a-ret-gel.html © Clearsky Pharmacy ( www.clearskypharmacy.biz )

10. A-Ret Gel (Generic Tretinoin Gel) Contraindications A-Ret gel is contraindicated in patients with a hypersensitivity to Tretinoin, hypersensitivity to retinoids or any inactive ingredient present in the cream. A-Ret gel is also contraindicated in the following cases: A-Ret gel is also contraindicated in the following cases: Women who are pregnant or Women planning a pregnancy. Tretinoin preparations have been reported to cause severe irritation of eczematous skin and should only be used with the utmost caution in patients with this condition. A-Ret gel should not be used in patients with a personal or family history of skin cancer. URL: URL: https://www.clearskypharmacy.biz/a-ret-gel.html https://www.clearskypharmacy.biz/a-ret-gel.html © Clearsky Pharmacy ( www.clearskypharmacy.biz )

11. A-Ret Gel (Generic Tretinoin Gel) Storage Instructions A-Ret gel (Generic Tretinoin 0.025%, 0.05% and 0.10% cream) have to be stored at controlled room temperature i.e. from 20°C to 25°C (68°F to 77°F) with excursions permitted between 15° to 30°C (59° to 86°F). Keep this as well as all other medicines away from children and pets. URL: URL: https://www.clearskypharmacy.biz/a-ret-gel.html https://www.clearskypharmacy.biz/a-ret-gel.html © Clearsky Pharmacy ( www.clearskypharmacy.biz )

12. A-Ret Gel (Generic Tretinoin Gel) Warnings A-Ret gel 0.025%, 0.05% and 0.1% should not be used on eczematous or sunburned skin due to potential for severe irritation. Avoid unprotected exposure to sunlight when using Tretinoin gel 0.05% due to potential for increased photosensitization. Use sunscreen of at least SPF 15 and protective clothing during exposure. Avoid use of Tretinoin gel with weather extremes, such as wind or cold due to potential for increased irritation. Use A-Ret gel 0.025%, 0.05% and 0.1% with caution if allergic to fish due to potential for allergenicity to fish protein. Patients who develop pruritus or urticaria should contact their health care provider. Topical tretinoin should be used by women of childbearing years only after contraceptive counseling. It is recommended that topical Tretinoin should not be used by pregnant women. URL: URL: https://www.clearskypharmacy.biz/a-ret-gel.html https://www.clearskypharmacy.biz/a-ret-gel.html © Clearsky Pharmacy ( www.clearskypharmacy.biz )

13. A-Ret Gel (Generic Tretinoin Gel) Side Effects The most common side effects with an incidence rate of 1% or greater with Tretinoin gel (A-Ret gel) are dry skin, peeling/scaling/flaking skin, skin burning sensation, erythema, Pruritus, Pain of Skin and Sunburn. The following side effects have been identified during post- The following side effects have been identified during post- approval use of Tretinoin gel: approval use of Tretinoin gel: Temporary hyper- or hypopigmentation has been reported with repeated application of Tretinoin. URL: URL: https://www.clearskypharmacy.biz/a-ret-gel.html https://www.clearskypharmacy.biz/a-ret-gel.html © Clearsky Pharmacy ( www.clearskypharmacy.biz )

14. A-Ret Gel (Generic Tretinoin Gel) Overdose If this medication is applied excessively, no more rapid or better results will be obtained and marked redness, peeling, or discomfort may occur. Oral ingestion of large amounts of Tretinoin gel ( A-Ret gel) may lead to the same side effects as those associated with excessive oral intake of Vitamin A. URL: URL: https://www.clearskypharmacy.biz/a-ret-gel.html https://www.clearskypharmacy.biz/a-ret-gel.html © Clearsky Pharmacy ( www.clearskypharmacy.biz )

15. A-Ret Gel (Generic Tretinoin Gel) A-Ret Gel During Pregnancy Tretinoin gel (A-Ret gel) has been classified by the US FDA as Pregnancy Category C. There are, however, no adequate and well-controlled studies in pregnant women. Tretinoin gel should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus. Thirty human cases of temporally associated congenital malformations have been reported during two decades of clinical use of Tretinoin gel. URL: URL: https://www.clearskypharmacy.biz/a-ret-gel.html https://www.clearskypharmacy.biz/a-ret-gel.html © Clearsky Pharmacy ( www.clearskypharmacy.biz )

16. A-Ret Gel (Generic Tretinoin Gel) A-Ret Gel click here For more details on A-Ret Gel click here A-Ret Gel (Tretinoin 0.025%, 0.05% and 0.10% gel) by Akums Drugs & Pharmaceuticals Limited, India and marketed by A. Menarini India Private Limited. URL: URL: https://www.clearskypharmacy.biz/a-ret-gel.html https://www.clearskypharmacy.biz/a-ret-gel.html © Clearsky Pharmacy ( www.clearskypharmacy.biz )