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Implementation Experiences & Insights from the Scale-Up of an HIV Assisted Partner Notification Intervention in Central Asia. 22 July 2019. Kristen M. Little, Maxim Kan, Olga Samoylova , Altynai Rsaldinova , Daniyar Saliev , Faridun Ishokov , Robert Gray, Nina S. Hasen.
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Implementation Experiences & Insights from the Scale-Up of an HIV Assisted Partner Notification Intervention in Central Asia 22 July 2019 Kristen M. Little, Maxim Kan, Olga Samoylova, AltynaiRsaldinova, Daniyar Saliev, FaridunIshokov, Robert Gray, Nina S. Hasen
Conflicts of Interest • I have no conflicts of interest to declare This work was supported by the USAID Central Asia HIV Flagship Activity Project (Contract Number: AID-176-C-16-0001)
Background • The HIV epidemics in Central Asia are highly concentrated • Disproportionately impact people who inject drugs (PWID) • Sexual partners of PWID • An estimated 168,600 PWID in Kazakhstan, the Kyrgyz Republic, and Tajikistan
Background HIV Prevalence among PWID 13.5% • HIV prevalence estimates among PWID range from 9.3%-13.5% • Compared to 0.13%-0.19% among the general population • Obstacles to HIV epidemic control • Laws and policies that discriminate against key populations • Stigma and marginalization that limit access to HIV services • Minimal epidemiological data to inform program design and targeting 9.3% Tajikistan Kazakhstan 12.4% Kyrgyz Republic
Background • WHO recommends assisted partner notification (APN) services for people living with HIV (PLHIV) • These services have not been widely scaled in Central Asia • We describe the results from an APN intervention implemented within a program focused on PLHIV and PWID in Kazakhstan, the Kyrgyz Republic, and Tajikistan • USAID-funded Flagship Project
Program Overview • Pre-APN Period: • Consenting index cases recruited sexual and injecting partners using passive referral • Coupon-based referral • APN Period: • Had choice of passive (coupon-based) referral or APN • APN included provider, contract, or dual-referral options
Methods To better understand differences in outcomes between the pre-APN and APN periods, we: • Analyzed de-identified routine program data before/after APN launch • Index cases and their sexual and injecting partners • Equal-length periods before and after APN intervention scaled • One month wash-out period during APN scale-up • Compared the demographic characteristics of index cases and sexual/injecting partners from pre-APN and APN periods, • Number/proportion of HIV cases found (positivity rate) • Comparison of index case characteristics before/after APN • Comparison of partner characteristics before/after APN • Estimated partners recruited per index case & the number of index cases needed to find one new partner with HIV
The number of index cases decreased under APN, while number of partners increased • Number of index cases recruited fell from 4,418 to 2,675 under APN • Partners recruited increased 1.7 times, from 2,245 to 3,735
Number of partners recruited per index case increased under APN • Increased from 0.5 partners per index in the pre-APN period to 1.4 under APN • Increase largest in KG (0.3 to 1.7) and TJ (0.3-1.6)
The number of index cases needed to find one positive partner decreased under APN • The number of index cases needed to find one new HIV+ partner fell from 27.4 during pre-APN to 8.3 under APN • Decreases seen across countries • Largest drops in KG (80%) and TJ (81%)
Limitations • Analysis based on routine monitoring data • Monitoring system not designed to link index cases to partners • Unable to assess whether differences among index cases accounted for improved outcomes • Unable to assess factors behind country-level heterogeneity • Did not collect information on the proportion of PLHIV agreeing to serve as index cases • No information on the proportion of index cases who recruited a partner • Risk behaviors based on self-report • Limited demographic and behavioral data collected • High missingness for some variables
Conclusions • APN services feasible in Central Asia • Able to be implemented alongside other HIV case-finding/management services • In context of PWID-focused HIV case-finding and management program • Though positivity rates varied across countries, APN resulted in: • Increases in the number of new HIV cases diagnosed among partners • Significant increases in number of partners recruited per index case • Significant reductions in number of index cases needed to find a new HIV-positive partner • Focusing additional resources on APN, using good practice tools and methods, may be feasible approach to improve HIV case-finding among hard-to-reach populations • Scale-up of APN services needed in Central Asia • More operational and implementation science research needed to optimize efficiency and effectiveness of APN in this setting
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Acknowledgements • Co-authors • Flagship and PSI staff • NGO implementing partners • Peer Navigators and clients in Central Asia • USAID