1 / 21

RBF = 1300 ml/min

RBF = 1300 ml/min. GFR = 125 ml/min V = 1 ml/min. Renal Resistance Vessels and the Intrarenal Hydraulic Pressure Profile. Glomerular Hemodyamics. RBF. P GC. Normal. Afferent Dilation. Afferent Constriction. Efferent Dilation. Efferent Constriction. Autoregulation.

clarke-stephenson
Download Presentation

RBF = 1300 ml/min

An Image/Link below is provided (as is) to download presentation Download Policy: Content on the Website is provided to you AS IS for your information and personal use and may not be sold / licensed / shared on other websites without getting consent from its author. Content is provided to you AS IS for your information and personal use only. Download presentation by click this link. While downloading, if for some reason you are not able to download a presentation, the publisher may have deleted the file from their server. During download, if you can't get a presentation, the file might be deleted by the publisher.

E N D

Presentation Transcript

  1. RBF = 1300 ml/min GFR = 125 ml/min V = 1 ml/min

  2. Renal Resistance Vessels and the Intrarenal Hydraulic Pressure Profile

  3. Glomerular Hemodyamics RBF PGC Normal Afferent Dilation Afferent Constriction Efferent Dilation Efferent Constriction

  4. Autoregulation

  5. Glomerular Permselectivity • Shape • Size • Charge

  6. Glomerular Permselectivity

  7. Glomerular Permselectivity Filtrate to plasma Concentration Ratio

  8. Glomerular Filtration • As described by Starling: • GFR = Kf {(PGC - PBC) - PGC} Kf = “Ultrafiltration Coefficient” PGC = Glomerular capillary hydraulic pressure PBC = Bowman’s capsule pressure PGC = Glomerular capillary oncotic pressure

  9. Filtration Equilibrium However, Driving forces along the axis of the glomerular capillaries are NOT constant.

  10. Filtration Equilibrium 1.Between afferent and efferent arteriole, plasma protein concentration and PGC rise. 2.Eventually NET driving forces favoring filtration are eliminated so that (PGC - PBC) = PGC.

  11. Glomerulus and Juxtaglomerular Apparatus • Regulatory Elements • Renal Arterioles / PGC • Macula Densa / TGF • Renin Secretion

  12. Tubulo-Glomerular Feedback Distal Flow AfferentResistance - PGC GFR

  13. Tubulo-Glomerular Feedback Afferent Resistance Distal Flow + PGC GFR

More Related