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Topic 2A Regulation of the Cell Cycle

Topic 2A Regulation of the Cell Cycle. Cyclin. Serine- threonine kinases # different types of cyclin Cyclin A, D and E—G1 S transition Cyclin B used in G2M transition Cyclin D is also called G1 cyclin Not expressed cyclically Synthesized by growth factor stimulation.

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Topic 2A Regulation of the Cell Cycle

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  1. Topic 2ARegulation of the Cell Cycle

  2. Cyclin • Serine-threoninekinases • # different types of cyclin • Cyclin A, D and E—G1S transition • Cyclin B used in G2M transition • Cyclin D is also called G1 cyclin • Not expressed cyclically • Synthesized by growth factor stimulation

  3. Activation of Cdks • Cyclin necessary but not sufficient • Must get a specific set of phosphorylations Cdc25 Wee-1 CAK

  4. DNA Replication Checkpoint • Monitors the state of DNA replication • Occurs between G2 and M • Inhibition of DNA replication • Phosphatase that catalyzes final step in mitotic Cdk-cyclin pathway is inhibited

  5. p53 = guardian of the genome • Extensive double-stranded DNA breaks triggers activation of ATM (ataxia telangiesctasia mutated) • SS-DNA breaks activates ATR (ATM-related protein) • ATM/ATR phosphorylate p53

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