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HIV Opportunistic infections

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HIV Opportunistic infections - PowerPoint PPT Presentation


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HIV Opportunistic infections. OIs- 10. OIs are the most common presentation of chronic treated HIV infection. OIs– 10. No. OIs - 20. OIs usually present when CD4< 300. OIs – 20. No usually when CD4 < 200. OIs - 30. The most common OI in HIV infection. OI – 30. Oral candidiasis.

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Presentation Transcript
ois 10
OIs- 10
  • OIs are the most common presentation of chronic treated HIV infection
ois 20
OIs - 20
  • OIs usually present when CD4< 300
ois 201
OIs – 20
  • No usually when CD4 < 200
ois 30
OIs - 30
  • The most common OI in HIV infection
oi 30
OI – 30
  • Oral candidiasis
oi 40
OI - 40
  • Name 2 of the most life threatening OIs
oi 401
OI– 40
  • PCP
  • Cryptococcosis
oi 50
OI- 50
  • CMV presents when CD4 < 50 and prophylaxis with antivirals should be started
oi 501
OI– 50
  • Antivirals are not part of prophylaxis for HIV related OIs
pcp 10
PCP - 10
  • One of the most common causes of death from AIDS in 80s
pcp 20
PCP- 20
  • PJP is a common environmental parasite
mhc 20
MHC – 20
  • IT is a fungus not a parasite
pcp 30
PCP- 30
  • Drug of choice for PCP prophylaxis and alternative if patient has allergy
pcp 40
PCP– 40
  • Diagnostic test of choice for PCP
pcp 401
PCP- 40
  • Diagnostic test of choice for PCP
pcp 402
PCP– 40
  • Sputum DFA for PCP
pcp 50
PCP- 50
  • One scenario that patient should stay on prophylaxis for PCP for life
pcp 501
PCP– 50
  • If patient had episode of PCP with CD4 > 200
cryptococcus 10
Cryptococcus- 10
  • The most common manifestation of cryptococcus infection
cryptococcus 101
Cryptococcus– 10
  • CNS infection
cryptococcus 20
Cryptococcus- 20
  • Why frequent LPs are needed with crypto meningitis?
cryptococcus 201
Cryptococcus– 20
  • Increased ICP
cryptococcus 30
Cryptococcus - 30
  • Name two diagnostic tests for Cryptococcus infection
cryptococcus 301
Cryptococcus– 30
  • Cryptococcus antigen
  • Fungal culture
cryptococcus 40
Cryptococcus - 40
  • Name the induction therapy for Cryptococcus
cryptococcus 401
Cryptococcus– 40
  • Amphotericin + 5FC
cryptococcus 50
Cryptococcus - 50
  • This regimen has been used in resource poor countries for treatment of Cryptococcus infection
cryptococcus 501
Cryptococcus– 50
  • High doses fluconazole (>800 mg) plus 5FC
toxoplasma 10
Toxoplasma- 10
  • Name 2 presentation of toxoplasmosis
toxoplasma 101
Toxoplasma- – 10
  • Fever, headaches, seizures, no clinical manifestations
toxoplasma 20
Toxoplasma - 20
  • A common carrier of toxoplasma (animal)
toxoplasma 30
Toxoplasma - 30
  • The antibiotic that is used for prophylaxis for Toxoplasma is also effective for other OIs
toxoplasma 301
Toxoplasma– 30
  • Bactrim is also effective against PCP
toxoplasma 40
Toxoplasma- 40
  • Name alternative antibiotics for Toxoplasma (if there is allergy to the drug of choice)
toxoplasma 401
Toxoplasma– 40
  • Clindamycin, pyrimethamine
toxoplasma 50
Toxoplasma- 50
  • Duration of prophylaxis for toxoplasma
toxoplasma 501
Toxoplasma- 50
  • Discontinue ppx when CD4>200 > 3 months