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Membran e Receptor for Antigen. Kelompok : 4 Ninda Sahri y ani (105090100111010 ) Ganys Tri S. (115090107111020) Agatha Mia (115090101111010) Vita Agustina ( 115090100111011) Jurusan Biologi Fakultas Matematika dan Ilmu pengetahuan Alam Universitas Brawijaya

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membran e receptor for antigen
MembraneReceptor for Antigen
  • Kelompok : 4
  • NindaSahriyani (105090100111010)
  • GanysTri S. (115090107111020)
  • Agatha Mia (115090101111010)
  • Vita Agustina(115090100111011)
  • Jurusan Biologi
  • Fakultas Matematika dan Ilmu pengetahuan Alam
  • Universitas Brawijaya
  • 2013
three limbs of immune respone
Three Limbs of immune respone

Fig 1. Three Limbs Immune Respone


Major Histocompatability Complex (MHC)

  • Group of genes that code for proteins that found on the surfaces of cells that help the immune system recognize foreign substances
  • Also known as HLA (Human Leukocyte Antigen)
  • Two types:

Function of MHC

  • Determinate between the self and nonself antigens
  • Presenting antigen to T cells
  • Determinate interaction between B cells, T cells and other cells.

Degradation Process (Processing and Presentation) Antigen

There are 3 ways of processing and presentation antigens :

  • Protein from extracellular pathogen broken down and processed by exogen pathway
  • Protein from self-protein and virus protein processed by endogen pathway
  • Lipid and derivate processed like extracelular protein and endosom, with CD1, that similiar to MHC and presented to CD8 T cell.

Function of MHC

similarities of antigen presenting by mhc molecules
Similarities of Antigen Presenting by MHC molecules
  • Presented to T cell on the surface of APC (Antigen Presenting Cell)
  • Every MHC can only bind to single antigen fragment at one time, at the peptide binding cleft
  • The presented antigen fragment is only amino acid chain
  • The binding is done intracellular

T Cell Receptor (TCR)

  • Mature T cell have thousands identical receptor on the cell surface
  • 2 kinds of receptor:
    • Alpha/beta (αβ) chain T cell (95%)
    • Gamma/delta (γδ) chain T cell (5%)
  • Co-receptor : CD4 and CD8

T Cell Receptor Complex: TCR-CD3

Fig 5. TCR-CD3

TCR binding to MHC-antigen

The long cytoplasmic tail of the CD3 functions in signal transduction.


Role of co-receptors in TCR binding affinity

Fig. 6 Role of co- receptor

CD 4 and CD8 : they may act as adhesion molecule helping the T cell bind to the APC during antigen presentation for duration that is sufficient for antigen recognition or act as signal transducers.


Link :

T Cell Dependent Antigens


Cytotoxic T Cell