membran e receptor for antigen n.
Download
Skip this Video
Loading SlideShow in 5 Seconds..
Membran e Receptor for Antigen PowerPoint Presentation
Download Presentation
Membran e Receptor for Antigen

Loading in 2 Seconds...

play fullscreen
1 / 15

Membran e Receptor for Antigen - PowerPoint PPT Presentation


  • 110 Views
  • Uploaded on

Membran e Receptor for Antigen. Kelompok : 4 Ninda Sahri y ani (105090100111010 ) Ganys Tri S. (115090107111020) Agatha Mia (115090101111010) Vita Agustina ( 115090100111011) Jurusan Biologi Fakultas Matematika dan Ilmu pengetahuan Alam Universitas Brawijaya

loader
I am the owner, or an agent authorized to act on behalf of the owner, of the copyrighted work described.
capcha
Download Presentation

PowerPoint Slideshow about 'Membran e Receptor for Antigen' - chin


An Image/Link below is provided (as is) to download presentation

Download Policy: Content on the Website is provided to you AS IS for your information and personal use and may not be sold / licensed / shared on other websites without getting consent from its author.While downloading, if for some reason you are not able to download a presentation, the publisher may have deleted the file from their server.


- - - - - - - - - - - - - - - - - - - - - - - - - - E N D - - - - - - - - - - - - - - - - - - - - - - - - - -
Presentation Transcript
membran e receptor for antigen
MembraneReceptor for Antigen
  • Kelompok : 4
  • NindaSahriyani (105090100111010)
  • GanysTri S. (115090107111020)
  • Agatha Mia (115090101111010)
  • Vita Agustina(115090100111011)
  • Jurusan Biologi
  • Fakultas Matematika dan Ilmu pengetahuan Alam
  • Universitas Brawijaya
  • 2013
three limbs of immune respone
Three Limbs of immune respone

Fig 1. Three Limbs Immune Respone

slide3

Major Histocompatability Complex (MHC)

  • Group of genes that code for proteins that found on the surfaces of cells that help the immune system recognize foreign substances
  • Also known as HLA (Human Leukocyte Antigen)
  • Two types:
slide4

Function of MHC

  • Determinate between the self and nonself antigens
  • Presenting antigen to T cells
  • Determinate interaction between B cells, T cells and other cells.
slide5

Degradation Process (Processing and Presentation) Antigen

There are 3 ways of processing and presentation antigens :

  • Protein from extracellular pathogen broken down and processed by exogen pathway
  • Protein from self-protein and virus protein processed by endogen pathway
  • Lipid and derivate processed like extracelular protein and endosom, with CD1, that similiar to MHC and presented to CD8 T cell.

Function of MHC

similarities of antigen presenting by mhc molecules
Similarities of Antigen Presenting by MHC molecules
  • Presented to T cell on the surface of APC (Antigen Presenting Cell)
  • Every MHC can only bind to single antigen fragment at one time, at the peptide binding cleft
  • The presented antigen fragment is only amino acid chain
  • The binding is done intracellular
slide11

T Cell Receptor (TCR)

T
  • Mature T cell have thousands identical receptor on the cell surface
  • 2 kinds of receptor:
    • Alpha/beta (αβ) chain T cell (95%)
    • Gamma/delta (γδ) chain T cell (5%)
  • Co-receptor : CD4 and CD8
slide12

T Cell Receptor Complex: TCR-CD3

Fig 5. TCR-CD3

TCR binding to MHC-antigen

The long cytoplasmic tail of the CD3 functions in signal transduction.

slide13

Role of co-receptors in TCR binding affinity

Fig. 6 Role of co- receptor

CD 4 and CD8 : they may act as adhesion molecule helping the T cell bind to the APC during antigen presentation for duration that is sufficient for antigen recognition or act as signal transducers.

video
VIDEO

Link :

T Cell Dependent Antigens

http://highered.mcgraw-hill.com/olc/dl/120

110/micro33.swf

Cytotoxic T Cell

http://highered.mcgraw-hill.com/olc/dl/120110/micro34.swf