In this patient, we would expect a diminished serum concentration of C-reactive protein.

1. Department of Pathology

2. An autopsy demonstrates fluid in the pulmonary alveoli of a patient who died of bacterial pneumonia.   Which one of the following is a true statement regarding this clinical situation: In this patient, we would expect a diminished serum concentration of C-reactive protein. The predominant type of leukocyte in the inflammatory response will be mononuclear leukocytes. In this clinical context, the fluid in the lungs will be an exudate. In this context, important opsonins for directing phagocytosis against the bacteria are interleukin-5 and eotaxin. 80-90% of the acute inflammatory responses to bacterial infections, in the lung, are granulomatous. Department of Pathology

3. Which of the following cell types is most important in the pathophysiology of early atherosclerotic lesions: Mast cells Fibroblasts Macrophages Red blood cells Stem cells Department of Pathology

4. A 70-year-old man is found to have an abdominal aortic aneurysm.  Which of the following factors is most predictive of aneurysm rupture in the next 3 months: Aneurysm length Aneurysm diameter Serum level of C reactive protein Serum level of Cholesterol Serum level of LDL Department of Pathology

5. A 70-year-old man is found to have an atherosclerotic plaque producing 90% luminal stenosis.  Which of the following blood vessels is most likely involved: Vena cava Jugular vein Popliteal artery Ocular capillaries Department of Pathology

6. A 70-year-old man has a posterior wall transmural myocardial infarction and dies 72 hours after the onset of symptoms as a result of cardiogenic shock.  At post mortem, examination of his heart would show: Circumferential infarction of the left ventricular subendocardium only Predominantly chronic inflammation in the infarct A ventricular aneurysm Coagulative necrosis with acute inflammation Predominantly macrophages and granulation tissue Department of Pathology

7. A 62-year-old man has a 40% decrease in the crossectional area of his Left anterior descending artery at a point 1 cm from its origin.  He is normotensive and otherwise in normal health. Based on these findings you would expect a moderate exercise challenge to: Cause a transmural myocardial infarct Cause a subendocardial myocardial infarct Cause anginal pain Precipitate an acute coronary syndrome Cause no symptoms Department of Pathology

8. The collagen that forms the fibrous cap of a mature atheroma is thought to be produced predominantly by: Neutrophils Platelets Smooth muscle cells Macrophages Endothelial cells Department of Pathology

9. A 19-year-old woman comes to the ED in acute distress.  Her blood pressure is 80/ 60 with a pulse of 180 beats per minute. Her skin is warm and dry.  Body temperature was 39 degrees C, and the WBC = 15,000 with 90% neutrophils. You suspect: Hypovolemic shock Septic shock Cardiogenic shock Department of Pathology

10.   In arteries supplying an end organ,  occlusivethrombi typically: Are characterized as red, or stasis, thrombi Propagate (extend) in direction of blood flow Are asymptomatic Result in infarction Are due to infectious organisms Department of Pathology

11. A previously healthy, tall, and slender 19-year old woman has the sudden onset of right-sided chest pain followed by progressive dyspnea. Ten hours later, an x-ray of the chest shows a collapsed right lung and air in the right pleural space. Which of the following is the most likely underlying condition? Bronchiectasis Lung abscess Panacinar emphysema Pulmonary sequestration Subpleural blebs Department of Pathology

12. A 12-year-old girl is admitted to the hospital because of marked shortness of breath, an erythematous rash, and painful, swollen hip and knee joints. She is agitated. A chest x-ray shows an enlarged heart and changes consistent with pulmonary edema. Intractable congestive heart failure develops, and she dies on the second hospital day. This child most likely had a recent history of which of the following? Cyanosis with chest pain Jaundice Meningitis Pharyngitis Skin infection Department of Pathology

13. A 55-year-old woman with breast cancer develops shortness of breath and poor exercise tolerance while being treated with doxorubicin.Which of the following is the most likely cause of these symptoms? Dilated cardiomyopathy Obstructive pulmonary disease Pulmonary hypertension Restrictive cardiomyopathy Restrictive pulmonary disease Department of Pathology

14. A 72 year old man collapses while playing golf. He has a long history of diabetes mellitus. EKG showed asystole. Paramedics arrive and resuscitation measures are initiated without success. Which of the following is the most likely cause of his death? Cardiac Tamponade Embolus to right middle cerebral artery Myocardial necrosis Papillary muscle rupture Ventricular fibrillation Department of Pathology