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Understanding Inhalant Abuse: Psychology and Adverse Effects

Delve into the disturbing world of inhalant abuse, from the late 50s to present-day risks, exploring the absorption, distribution, and neurophysiological impacts of these harmful substances. Learn about behavioral effects, prevention strategies, and the challenges of treatment.

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Understanding Inhalant Abuse: Psychology and Adverse Effects

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  1. Inhalants Psychology 3506

  2. Introduction • OK, now this is depressing…. • Solvents, paints, nail polish remover, gasoline, lighter fluid… • Late 50’s the media and cops picked up on glue sniffing, which seemed to have increased the amount of glue sniffed…. • Same with aerosols in the 1970s • Now it is gasoline

  3. Administration • Sniffing • Huffing • Swallowing • Cloth can make sure you get fresh air • Bag concentrates it • From aerosol can too

  4. Absorption, Distribution and Excretion • Absorbed into lungs • Passed quickly to brain • Concentration in blood approaches concentration in air • Fatty tissue get the most (due to high lipid solubility) • Brain • liver

  5. Absorption, Distribution and Excretion • Concentrations also drop quickly • Through the lungs • More blood flow, faster reduction • Toluene for example is metabolized in the liver though, most not exhaled • Liver creates metabolites that may be toxic

  6. Neurophysiology • Effects seem similar to alcohol and tranquilizers • Enhance GABA • Enhance glycine • Attenuate NMDA receptor for glutamate • Seems to affect DA in mesolimbic dopamine system, but how, we dunno

  7. Behavioural Effects • Like alcohol • Hallucinations • Seizures • Stupor • Death • Probably impairs driving

  8. Effects, continued • Tolerance, maybe • Withdrawal, maybe • Psychotic behaviour • Cancer • Kidney damage • FSS? • OD

  9. Prevention and Treatment • Nasty additives • Education • Treatment is really tough • They have lots of other problems usually • May take many attempts

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