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Gout Renal failure PowerPoint Presentation
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Gout Renal failure

Gout Renal failure

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Gout Renal failure

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  1. Supplementary Fig. 1 A † Gout † Gout Gout Renal failure † N.E. N.E. Gout Renal failure Propositus Gout Hyperuricemia Gout Renal failure

  2. GA Supplementary Fig. 1 B Cys112Tyr G335A Exon2 Exon 3 Exon4 Exon 5-8 Leader Peptide EGF-like Cys-rich Zona Pellucida CCS YY Y Y Y GPI EHP Y Y EGF1 cbEGF2 cbEGF3 D8C ZP-C ATG ZP-N 22 31 281 334 426 505 585 614 640 C112Y IHP

  3. Supplementary Fig. 2 WT C112Y WT C112Y MG132 - - + + soluble 75KDa- uromodulin insoluble 75KDa-

  4. Supplementary Fig. 3 WT C112Y Cell lysate Vector P + + Lactacystin - - Uromodulin 75KDa- GFP β-actin

  5. Supplemental Fig.4 WT C112Y Topiroxostat (30μM) - + - + Uromodulin 75kDa- Secreted Uromodulin 75kDa- GFP β-acin