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Fungi 3 Lecture 26 Summer, 2006

Fungi 3 Lecture 26 Summer, 2006. Demosthenes Pappagianis, MD, PhD MMI 480B. The scope of medically important fungi. Select Agents for Bioterrorism…. Domingo Escurra first patient with Coccidioidomycosis. Domingo Escurra. Alejandro Posadas. D.P and D. Stevens with Domingo Escurra.

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Fungi 3 Lecture 26 Summer, 2006

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  1. Fungi 3Lecture 26Summer, 2006 Demosthenes Pappagianis, MD, PhD MMI 480B

  2. The scope of medically important fungi

  3. Select Agents for Bioterrorism….

  4. Domingo Escurra first patient with Coccidioidomycosis

  5. Domingo Escurra

  6. Alejandro Posadas

  7. D.P and D. Stevens with Domingo Escurra

  8. Joao Silveira

  9. Spherule of Coccidioides immitis

  10. Sputum culture Coccidioides immitis

  11. Hyphae/arthroconidiaCoccidioides immitis

  12. Life CycleCoccidioides immitis in vivo - 48-72 hours in vitro - 32-96 hours

  13. Coccidioidomycosis -Spectrum of Disease

  14. Primary Pulmonary Coccidioidomycosis

  15. CoccidioidalErythema Nodosum

  16. Palmar coccidioidalmacules/urticarial - thighs

  17. Coccidioidomycosis - patella

  18. Spherule of Coccidioides immitis

  19. DNA Probe

  20. Serologic Sequence of Antibody Coccidioidomycosis

  21. Animal species with naturally acquired coccidioidomycosis

  22. Endemic Areas

  23. Dye Creek California Endemic Areas Soledad Paso Robles Avenal Coalinga Calif. Men’s Colony Corcoran Otay Tecate

  24. Simi Valley Northridge earthquake 1994

  25. Histoplasma capsulatumin macrophage

  26. Histoplasma capsulatum intracellular-adrenal macrophages

  27. H. capsulatum hyphae, tuberculate macroconidia

  28. 3 months later healed Acute histoplasmosis

  29. healed, calcified Acute histoplasmosis

  30. Ulcerative histoplasmosis - mouth

  31. H. capsulatum adrenal Methenamine silver H&E

  32. Serologic reaction histoplasmosis HAg - histoplasmal antigen HAb - histoplasmal antibody CAg - coccidioidal antigen CAb - coccidioidal antibody Bubbles indicate catalase

  33. Histoplasmosis - world

  34. Histoplasmosis endemic Western hemisphere

  35. Blastomyces dermatitidisyeast phase

  36. B. dermatitidis yeast phasepus/KOH

  37. B. dermatitidis mold, hyphae, conidia

  38. Blastomycosis – facial lesion

  39. Blastomycosis – crustedpyogranulomatous lesions - extremities

  40. Endemic AreasBlastomycosisin USAand Canada

  41. Paracoccidioides brasiliensisyeast phase

  42. Paracoccidioides brasiliensismixed inflammation

  43. Paracoccidioides brasiliensishyphae/conidia

  44. Paracoccidioides brasiliensismorphogenesis

  45. Paracoccidioidermycosismucocutaneous

  46. Paracoccidioides brasiliensis -geographic distribution

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