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Analysis of CD4+/CD8+ T Cell Responses in HIV Infection: IL-2 to IFNg Ratios

This study investigates the ratios of IL-2+ to IFNg+ CD4+ and CD8+ T cells in patients with HIV and their correlation with pp65 and IE-1 antigen responses. The focus is on comparing ratios in HIV-negative individuals versus positive patients, highlighting immune responses involved in HIV infection. We present data on the frequency of CD4+ and CD8+ T cells expressing key cytokines both in the context of HIV-specific antigens (pp65, IE-1, Gag, and Env) and without, providing insights into potential pathways for immune modulation.

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Analysis of CD4+/CD8+ T Cell Responses in HIV Infection: IL-2 to IFNg Ratios

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  1. CD4+ 1.00 0.75 Ratio of IL-2+ to IFNg+ cells 0.50 0.25 0.00 HIV- pp65+IE-1 HIV+ pp65+IE-1 HIV+ Gag+Env CD8+ 0.4 0.0005 0.3 Ratio of IL-2+ to IFNg+ cells 0.2 0.1 0.0 HIV- pp65+IE-1 HIV+ pp65+IE-1 HIV+ Gag+Env

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