Discovery of G-proteins and the role of these proteins in signal transduction Martin Rodbell & Alfred G. Gilman. Wen-Chun Shaw Dr. VanKley Scientific Discovery. What is G-protein??. G-protein coupled receptor signaling. (A). (B). (C). (D). G-protein coupled receptor. GPCR and Disease.
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Cholera is caused by a comma-shaped bacterium, Vibrio cholerae, which is ingested in contaminated water and food. The bacteria multiply enormously in the intestine, where epithelial cells allow fluid to leak into the
intestine with intense diarrhoea as a result. Cholera is endemic in India and other parts of the third world.
4. Scientists have found that the mutation affects the same G-protein involved in cholera. This G-protein gets active continuously.
5. Skin cells, this causes darker pigment. G-protein involved in cholera. This G-protein gets active continuously.
6. Bone cells, it causes weakness and fractures.
7. Hormone-producing cells
the mutation causes
the release of excess
Paul Enrlich (1854-1915).
his work on immunity
for which he was awarded
the Nobel Prize for Medicine
/Physiology in 1908
the development of selective
especially against syphilis and
the foundation of haematology
through his use of new dye staining techniques.
Lock and Key
Group(I) Unfed, ON Group(II) fed
β times faster than ATP
GPCRs are good drug targets
50% of subscription drugs interact with GPCR
GPCRs in disease states times faster than ATP