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Choosing a donor for SCT. Paul Veys Director Blood and Marrow Transplantation GOSH Honorary Clinical Professor UCL. Sibling donor. No Transplant. Unrelated cord blood. Mismatched family donor “Haploidentical”. Volunteer unrelated donor. Creation of “saviour sibling” Gene therapy.

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choosing a donor for sct

Choosing a donor for SCT

Paul Veys

Director Blood and Marrow Transplantation GOSH

Honorary Clinical Professor UCL

slide2

Sibling donor

No Transplant

Unrelated cord blood

Mismatched family donor

“Haploidentical”

Volunteer unrelated donor

Creation of “saviour sibling”

Gene therapy

slide3
Allogeneic transplants in patients £20 years,by donor type and graft source, registered with CIBMTR, 1991-2008

5,000

Related, BM or PB

Unrelated, BM or PB

Unrelated, CB

4,500

4,000

3,500

3,000

Number of Transplants

Number of Transplants

2,500

2,000

1,500

1,000

500

0

*

* Data incomplete

1991-92

1993-94

1995-96

1997-98

1999-00

2001-02

2003-04

2005-06

2007-08

Slide 12

SUM10_14.ppt

slide4

Outcomes by year: sibling vs unrelatedOne-year survival after myeloablative conditioning for acute leukemias in any remission phase, CML or MDS, age <50 years, by year of transplant and graft source, 1988-2008

100

Sibling Donor

Unrelated Donor

80

60

One-Year Survival, %

40

20

0

1988-90

1991

1992

1993

1994

1995

1996

1997

1998

1999

2000

2001

2002

2003

2004

2005

2006

2007

2008

Slide 16

SUM10_18.ppt

potential advantages and disadvantages of different types of stem cell donor
Potential advantages and disadvantages of different types of stem cell donor

British Journal of Haematology 2003; 123: 193-206

Bone Marrow Transplantation 2006; 37: 90-908

British Journal of Haematology 2009; Aug 25.