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Glucose Independent Insulin Secretion

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Glucose Independent Insulin Secretion - PowerPoint PPT Presentation


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Beta Protective. Glucose Independent Insulin Secretion. May combine up to max three oral agents. Glucosidase Inhibitors +Dec PP BG -Poor Tolerance. Incretins +Glu Dep Insulin +Appetite Dec -GI Upset. DPP-IV Inhibitors +Glu Dep Insulin -Upper Resp Inf. Glinides -Cost. A1C <1.0.

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Presentation Transcript
slide1

Beta Protective

Glucose

Independent

Insulin Secretion

May combine up to max three oral agents

Glucosidase

Inhibitors

+Dec PP BG

-Poor Tolerance

Incretins

+Glu Dep Insulin

+Appetite Dec

-GI Upset

DPP-IV

Inhibitors

+Glu Dep Insulin

-Upper Resp Inf

Glinides

-Cost

A1C <1.0

A1C >1.5

Insulin

+Efficacy

-Hypoglycemia

TZDs

+No Hypo

-Cardiac Risk

SU

+Cost

-Hypoglycemia

-STEMI Masking

Metformin & TLC