Manufacture of hard gelatin capsules

1. Manufacture of hard gelatin capsules Preparation of the gelatin solution Initially a concentrated solution of gelatin is prepared (circa 35–40% w/w) in demineralised hot water with stirring. Following dissolution of the polymer a vacuum is then applied to the mixing vessel to remove entrapped air. Incorporation of other constituents of the capsule Other excipients may be included within the heated gelatin solution, Wetting agents/lubricants. It is permissible to formulate hard gelatin capsules with sodium lauryl sulphate ( 0.15% w/w) as an included component to increase the wetting properties of the capsule shell following contact with an aqueous solution (and hence enhance the dissolution properties of the formulation contained within the capsule). Furthermore, the presence of sodium lauryl sulphate in the heated gelatin solution will also enhance the wetting of the (hydrophilic) gelatin solution on the metal pins during the manufacturing process. Visit:www.capsuleusa.com