1 / 19

Cellular Respiration Electron Transport Chain

Cellular Respiration Electron Transport Chain. Cellular respiration. What’s the point?. The Point is to Make ATP!. ATP. What’s the Point?. ATP accounting so far…. Glycolysis  2 ATP Kreb’s cycle  2 ATP Life takes a lot of energy to run, need to extract more energy than 4 ATP !

cais
Download Presentation

Cellular Respiration Electron Transport Chain

An Image/Link below is provided (as is) to download presentation Download Policy: Content on the Website is provided to you AS IS for your information and personal use and may not be sold / licensed / shared on other websites without getting consent from its author. Content is provided to you AS IS for your information and personal use only. Download presentation by click this link. While downloading, if for some reason you are not able to download a presentation, the publisher may have deleted the file from their server. During download, if you can't get a presentation, the file might be deleted by the publisher.

E N D

Presentation Transcript


  1. Cellular Respiration Electron Transport Chain

  2. Cellular respiration

  3. What’s the point? The Point is to Make ATP! ATP

  4. What’s thePoint? ATP accounting so far… • Glycolysis 2ATP • Kreb’s cycle 2ATP • Life takes a lot of energy to run, need to extract more energy than 4 ATP! There’s got to be a better way!

  5. Thatsounds morelike it! There is a better way! • Electron Transport Chain • series of molecules built into inner mitochondrial membrane • mostly transport proteins • transport of electrons down ETC linked to ATP synthesis • yields ~34ATP from 1 glucose! • only in presence of O2 (aerobic)

  6. Mitochondria • Double membrane • outer membrane • inner membrane • highly folded cristae* • fluid-filled space between membranes = intermembranespace • matrix • central fluid-filled space * form fits function!

  7. Electron Transport Chain

  8. Remember the NADH? Kreb’s cycle Glycolysis PGAL 8 NADH 2 FADH2 4 NADH

  9. Electron Transport Chain • NADH passes electrons to ETC • H cleaved off NADH & FADH2 • electrons stripped from H atoms  H+ (H ions) • electrons passed from one electron carrier to next in mitochondrial membrane (ETC) • transport proteins in membrane pump H+ across inner membrane to intermembrane space

  10. electrons flowdownhill toO2 But what “pulls” the electrons down the ETC?

  11. Electrons flow downhill • Electrons move in steps from carrier to carrier downhill to O2 • each carrier more electronegative • controlled oxidation • controlled release of energy

  12. Why the build up H+? • ATP synthase • enzyme in inner membrane of mitochondria ADP+PiATP • only channel permeable to H+ • H+ flow down concentration gradient = provides energy for ATP synthesis • molecular power generator! • flow like water over water wheel • flowing H+ cause change in shape of ATP synthase enzyme • powers bonding of Pi to ADP • “proton-motive” force

  13. So that’sthe point! ATP synthesis • Chemiosmosis couples ETC to ATP synthesis • build up of H+ gradient just so H+ could flow through ATP synthase enzyme to build ATP

  14. 1961 | 1978 Peter Mitchell • Proposed chemiosmotic hypothesis • revolutionary idea at the time proton motive force 1920-1992

  15. Cellular respiration

  16. C6H12O6 + 6CO2 + 6H2O + ~36 ATP 6O2 Summary of cellular respiration • Where did the glucose come from? • Where did the O2 come from? • Where did the CO2 come from? • Where did the H2O come from? • Where did the ATP come from? • What else is produced that is not listed in this equation? • Why do we breathe?

  17. Taking it beyond… • What is the final electron acceptor in electron transport chain? O2 • So what happens if O2 unavailable? • ETC backs up • ATP production ceases • cells run out of energy • and you die!

  18. What’s the point? The Point is to Make ATP! ATP

  19. Any Questions??

More Related