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Electron Transport chain Critical elements source of electrons Redox potentials Membrane potentials Proton transport ATP synthesis More Bits Q- Cycle Transport cycles of essential elements Chemiosmotic theory Worth two Chemistry Nobel prizes

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electron transport chain
Electron Transport chain
  • Critical elements
    • source of electrons
      • Redox potentials
    • Membrane potentials
    • Proton transport
    • ATP synthesis
more bits
More Bits
  • Q- Cycle
  • Transport cycles of essential elements
  • Chemiosmotic theory
    • Worth two Chemistry Nobel prizes
      • 1978 Peter Mitchell Nobody believed it for the first 10 years
      • 1997 to Paul D. Boyer and John E. Walker. Elucidation of FoF1 ATPase mechnism
  • Amazingly efficient ≈70% DG captured under physiological conditions (cars are < 30%)
slide4

Nerst equation

    • E’=Eo’– (2.3RT/nF)Log [Red]/[Oxi]
  • E’=Eo’– (0.059V/n)Log [Red]/[Oxi]
    • E’=Eo’- (RT/nF)ln [Red]/[Oxi]
  • Conversion of DE to DG
    • DG= -nFDE’
figure 22 2b
Figure 22-2b

Page 799

transport
NADH in

Calcium Balance|

Pi in

ADP in ATP out

Acetyl-S-CoA out

Malate aspatate shuttle/glycerolphosphate shuttle

Na/Ca exchange outTran/sys in

Phosphate carrier /DH+

Adenine Nucleotide Translocase

Citrate/pyruvate transport

Transport
glycyrol 3 phosphate shuttle
Glycyrol 3 phosphate shuttle

DHAP  Glycerol 3 phosphate

Glycerol 3 phosphate  DHAP

FADH  FAD

Membrane bound Complex II

Nad NadH

Co Enzyme Q

figure 22 1
Figure 22-1

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slide13
Figure 22-13 Determination of the stoichiometry of coupled oxidation and phosphorylation (the P/O ratio) with different electron donors.

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slide14

Electron Transport Chain

  • 4 complexes
    • Complex 1
      • entry point of NADH
      • pumps 2-4 protons
      • inhibited by rotenone of amatal
    • Complex 2
      • Succinate Dehydrogenase
      • Entry point of FADH2
      • reduces CoQ/Ubiquinone
slide15

Electron Transport Chain

  • 4 complexes
    • Complex 3
      • bc1 complex
      • Pumps 2-4 protons
      • Involved in Q Cycle Passes electrons to Cyt
      • Inhibited by Antimycin A
    • Complex 4

Oxygen reduction complex

Cytochrome a a1

Copper containing proteins

Inhibited By Cyanide

electron transport chain16
Electron transport chain
  • NAD+ + H+ + 2e- <---> NADH [-0.32 V]
  • FAD + 2H+ + 2e- <---> FADH2 [-0.22 V]
  • FMN + 2H+ + 2e- <---> FMNH2 [-0.12 V]
  • CoQ + 2H+ + 2e- <---> CoQH2 [+0.10 V]
  • Cyt c (Fe3+) + e- <---> Cyt c (Fe2+) [+0.22 V]
  • Cyt a (Fe3+) + e- <---> Cyt a (Fe2+) [+0.29 V]
  • O2 + 2H+ + 2e- <---> H2O [+0.82 V]
figure 22 9
Figure 22-9

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