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The road to DNA, its importance and structure

Explore the significance and structure of DNA, from Griffith's early findings to the revolutionary double helix model by Watson and Crick in 1953. Learn about Chargaff's base pair rules, Hershey and Chase's experiments, Franklin's X-ray crystallography, and much more in the journey towards understanding DNA's role in genetics.

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The road to DNA, its importance and structure

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  1. The road to DNA, its importance and structure

  2. Griffith, Avery, Macleod 1944 • Transformation: DNA could transform cells whereas proteins could not

  3. Chargaff: 1947 • Equal % of C and G • Equal % of A and T

  4. Hershey and Chase: 1952

  5. Franklin’s X-ray crystallography: early 1950’s Had to be able to crystalize molecule Regular pattern= helix

  6. Waston and crick: 1953 • Double helix model

  7. Messelson and Stahl: late 1950’s: Semi-conservative replication

  8. Chromosome structure: later

  9. DNA structure • Antiparallel: opposite directions

  10. Complementary: base pairs • Always one purine (double ring) A or G • Always one pyrimidine (single ring) C or T • A/T only has two H bonds so it is easier to unzip.

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