1 / 13

Varicocèle nouveautés en 2019

Varicocèle nouveautés en 2019. Béatrice Cuzin, Service d’Urologie et de la transplantation, Lyon, France.

bush
Download Presentation

Varicocèle nouveautés en 2019

An Image/Link below is provided (as is) to download presentation Download Policy: Content on the Website is provided to you AS IS for your information and personal use and may not be sold / licensed / shared on other websites without getting consent from its author. Content is provided to you AS IS for your information and personal use only. Download presentation by click this link. While downloading, if for some reason you are not able to download a presentation, the publisher may have deleted the file from their server. During download, if you can't get a presentation, the file might be deleted by the publisher.

E N D

Presentation Transcript

  1. Varicocèle nouveautés en 2019 Béatrice Cuzin, Service d’Urologie et de la transplantation, Lyon, France

  2. Treatment of Varicocele in Children and Adolescents: A SystematicReview and Meta-analysisfrom the European Association ofUrology/European Society for PaediatricUrology Guidelines PanelMS Silay et coll 2019

  3. The diagnosis of male infertility: an analysis of the evidence to supportthe development of global WHOguidance—challenges and futureresearchopportunitiesChristopher LR Barrat et coll 2017

  4. The diagnosis of male infertility: an analysis of the evidence to supportthe development of global WHOguidance—challenges and futureresearchopportunitiesChristopher LR Barrat et coll 2017

  5. Treatment of varicoceles: techniquesand outcomesDane Johnson et coll 2017 CONCLUSION Thoughstillsomewhatcontroversial, mostevidence supports the treatment of clinically palpable varicoceles in the context of male-factor infertility. There isalso good evidence for treatment in symptomaticvaricoceles, as well as in adolescents withtesticulargrowth retardation and/or abnormalsemenparameters. Althoughmost techniques have similarresults in terms of outcome, each has itsownadvantages and disadvantages, and itis up to the provider and the patient to determinewhatwillwork best for them. Furtherstudies,includingpredictivefactors for success, more objective ways to diagnose, as well as nontraditionalmeasures of success (e.g., decreased DNAF, improvedtesticularfunction) are needed to help us to betterunderstandthis condition.

  6. Prise en charge de la varicocèle B. Cuzin EMC 2018

  7. Prise en charge de la varicocèle B. Cuzin EMC 2018

  8. Effect of varicocelerepair on sperm DNA fragmentation: a reviewM Roques et coll 2018

  9. Effect of varicocelerepair on sperm DNA fragmentation: a reviewM Roques et coll 2018 Abstract Varicocele, the leading cause of male infertility, can impair spermquality and fertility via variousoxidative stress mechanisms. An imbalancebetween excessive reactiveoxygenspecies production and antioxidant protection causes alterations in nuclear and mitochondrial sperm DNA, thusrendering a subset of varicocele men less fertile. In particular, spermDNAfragmentationisusuallyelevated in men withclinicalvaricocele in bothabnormal and normal semenparameters by thecurrent World HealthOrganizationcriteria. In thisreview, wediscuss the evidenceconcerning the association betweenvaricocele, oxidative stress, and SDF, and the possible mechanismsinvolved in infertility. Furthermore, wesummarizetherole of varicocelerepair as a means of alleviating SDF and improvingfertility. Lastly, wecriticallyappraise the evidencebasedalgorithmrecentlyissued by the Society for TranslationalMedicineaimed at guidingurologists on the use of SDF testing in men withvaricoceleseekingfertility. Currentevidencebased on carefulreview of publishedstudiesconfirms the effectiveness of varicocelectomy as a means of bothreducingoxidativelyinducedsperm DNA damage and potentiallyimprovingfertility. Varicocelerepairshouldbeoffered as part of treatment option for male partners of infertile couples presentingwith palpable varicoceles.

  10. Effect of varicocelerepair on sperm DNA fragmentation: a reviewM Roques et coll 2018

  11. Prise en charge du varicocèle: Pas de changement majeur Intéret du traitement sur la fragmentation Discuter selon les conditions de la technique de traitement Intérêt des méthodes de consensus

More Related