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Gary H. Glover, Ph.D. Director, Radiological Sciences Laboratory

Functional MRI Research. Gary H. Glover, Ph.D. Director, Radiological Sciences Laboratory. Center for Advanced MR Technology* rsl.stanford.edu/research/camrt.html Stanford University School of Medicine Department of Radiology. *. fMRI research in my lab.

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Gary H. Glover, Ph.D. Director, Radiological Sciences Laboratory

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  1. Functional MRI Research Gary H. Glover, Ph.D. Director, Radiological Sciences Laboratory Center for Advanced MR Technology* rsl.stanford.edu/research/camrt.html Stanford University School of Medicine Department of Radiology *

  2. fMRI research in my lab Methodology of fMRI acquisition, analysis, exp. design Neuro, breast

  3. SNR Spiral vs. EPI EPI Spiral

  4. Activation 1.5T 3.0T 0.25 ≤ cc ≤ 0.70

  5. Brain Noise at 3T Thermal noise 0 Phys. noise B Phys. noise NB Krueger (MRM 2001) Single-shot spiral: 64x64, TR 3000, TE 30

  6. Resting State 0.35 ≤ r ≤ 0.7, p<.0.0005 p/q18944.12110704

  7. Default-Mode Network in AD healthy aging (A) AD (B) Greicius et al., PNAS, 2004

  8. Mt SPIRAL OUT Susceptibility Effects TE RF SPIRAL OUT Gx RF SPIRAL IN Gx C. Law, 2002

  9. Novel vs. Repeated Pictures Out In-Out A. Preston, 7/02

  10. Verbal Working Memory Task sprl-out sprl in-out 3T M. Thomason

  11. sparse temporal (STS) stim scan Sparse Temporal Sampling stim event related scan . . . . stim clustered scan Nadine Gaab

  12. Pitch Memory 1 scan, 1 sec frames -5s to 5s p = 0.0003 Nadine Gaab

  13. Activation Time series

  14. rtfMRI System GE Signa 3T Spiral Recon 1 vol./TR 16 slc/s Postprocessing response physio monitor stimuli gen TCP/IP HR, resp. GSR, EMG Visual/audio stimuli Response devices

  15. rtfMRI Interface

  16. A) Pre-Training B) Post-Training R L R L Average Average 2 .6 2 .6 .4 .4 % signal 1 1 % signal Δ .2 .2 -1 -1 0 0 -2 -2 1 EMG, mV 0 -1 rtfMRI TRAINING SINGLE SUBJECT RESULTS deCharms et al, NI (2004)

  17. C5-C6 Mid-C5 C4-C5 fMRI Results – Noxious Thermal Stimulation Anterior Cingulate Somatosensory Cortex Mackey, et al, (2004)

  18. Effect of training (INCREASE – DECREASE) last run VS. (INCREASE – DECREASE) first training run L

  19. 0.6 * † 0.5 0.4 rACC activation (BOLD) 0.3 0.2 0.1 0 Training run 1 Training run 2 Training run 3 Final test run 4 50 * * † 40 30 Pain intensity rating (% difference) 20 10 0 -10 Training run 1 Training run 2 Training run 3 Final test run 4 Pain vs. activation in rostral anterior cingulate

  20. 7T Dreaming

  21. 7T 230m x 230m x1000m Courtesy Tie-Qian Li, NIH, 2005

  22. 500 m, 7T Josef Pfeuffer, et al CMRR, UMN 7T 900 m, 7T Josef Pfeuffer, et al CMRR, UMN

  23. fMRI research in my lab Methodology of fMRI acquisition, analysis, exp. design • some projects not shown: - BH challenge - fetal fMRI - TMS/fMRI - high res. fMRI - EEG/fMRI - localized shimming - 3D fMRI - Breast BOLD contrast • collaborations with many on campus • opportunities for rotation projects

  24. My kids 7/2005

  25. fMRI studies at Lucas • ~25 PI’s in Psychology, Psychiatry, Neuroradiology, Neurosurgery, Neurobiology, Neurosciences • Currently ~110 students/postdocs, others • 220 members of fmri-group@lists.stanford.edu

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