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Changing Epidemiology: The Importance of Broad Spectrum Therapeutics . Cornelia Lass-Flörl Innsbruck Medical University. Candidiasis. Aspergillosis. Incidence of Fatal Invasive Mycoses in USA. Mc Neil et al 2001 Clin Infect Dis 33;641. Incidence of Invasive Mycoses .
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Innsbruck Medical University
Incidence per 100.000 population
Pfaller, ICAAC M 1805, 2006
The medically most important opportunistic mycoses in Europe are caused by Aspergillus spp. and Candida spp.
Aspergillus spp.A.fumigatus is the most common etiologic agent (80-90%), other species are A.flavus (10-15%), A.terreus (2-5%), A.niger (1-2%).
Candida spp.C. albicans, with an increasing incidence of
C. glabrata , C. tropicalis and C. krusei.
Kullberg et al. Epidemiology of opportunistic invasive mycosis.
Europ. J Med. Research, 2002
BSI=blood stream infection.
Surveillance and Control of Pathogens of Epidemiologic Importance (SCOPE) study.
Wisplinghoff H, et al. Clin Infect Dis. 2004;39:309-317.
Number of isolates (% of species)
Bassetti M et al. BMC Infectious Diseases 2006:1-6.
Causes biofilms which usually require removal of catheters etc, as antifungal drugs are ineffective in eradicating biofilmsBiofilms and Candida parapsilosis
Pfaller 2006, Pfaller 2007
Other speciesEvolution of Isolation of Candida Species in Relation to Fluconazole Consumption
Sendid B et al. BMC Infectious Diseases 2006:61-9.
Singh & Paterson. Clin Microbiol Rev. 2005 18:44-69.
Lass-Flörl et al,submitted, 2007
Bone marrow transplantation
Solid organ transplantation
Initial presentation with sinusitis
Occurrence as breakthrough prior VRC prophylaxis
Marr, CID 2002
Steinbach, J Infect 2004
Roden, et al. Clin Inf Dis 2005;41:634-53.
Kontoyiannis et al. JID, 2005; 191:1350-60.
Siwek et al. CID 2004; 39:584-87.
Sun QN et al. AAC 2002; 46: 1581–1582.
Williamson, Thorax 1997;52:229.
Taskinen, Acta Paediatr 1999; 88:1373.
Oren, Am J Hematol 2001; Anaissie, CID 2002.
Singh 2001; Denning 2005, Kontoyiannis 2005, Lass-Flörl 2005
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