1 / 7

ATHEROSCLEROTIC DISEASE - THE SIZE OF THE PROBLEM

ATHEROSCLEROTIC DISEASE - THE SIZE OF THE PROBLEM. Vascular Event Incidence and Prevalence • Stroke 0.24% of the population per year suffer a stroke for the first time 25% of men and 20% of women over 45 years will have a stroke by the age of 85 years

bridie
Download Presentation

ATHEROSCLEROTIC DISEASE - THE SIZE OF THE PROBLEM

An Image/Link below is provided (as is) to download presentation Download Policy: Content on the Website is provided to you AS IS for your information and personal use and may not be sold / licensed / shared on other websites without getting consent from its author. Content is provided to you AS IS for your information and personal use only. Download presentation by click this link. While downloading, if for some reason you are not able to download a presentation, the publisher may have deleted the file from their server. During download, if you can't get a presentation, the file might be deleted by the publisher.

E N D

Presentation Transcript

  1. ATHEROSCLEROTIC DISEASE - THE SIZE OF THE PROBLEM Vascular EventIncidence and Prevalence • Stroke 0.24% of the population per year suffer a stroke for the first time 25% of men and 20% of women over 45 years will have a stroke by the age of 85 years • Myocardial 0.56% of the population experience an MI per year Infarction 2.4% of the population have suffered an MI • Peripheral Symptomatic PVD increases with age: Vascular - 0.2% per year in men of 35-45 years Disease - 7% of 50-75 year-olds Office for National Statistics. Britain 1998. HMSO, London 1998; Stroke Services and Research. London 1996; Coronary heart disease statistics. BHF 1995; Lancet 1997;350:1469-65; Eur J Vasc Surg 1988;2:283-291. 11604 PLA99/069 a

  2. Coronary artery disease 21% 9% 8% 5% Peripheral vascular disease Cerebrovascular disease 8% 3% 9% CO-EXISTENCE OF CORONARY, CEREBRAL, AND PERIPHERAL VASCULAR DISEASE Prevalence of vascular disease in a population 62 years of age and over n = 1886 Am J Cardiol 1994;74:64-65 11604 PLA99/069 b

  3. ATHEROSCLEROTIC DISEASE Multiple Clinical Outcomes - One Underlying Pathology 11604 PLA99/069 c

  4. ATHEROSCLEROTIC PLAQUE FORMATION 11604 PLA99/069 g

  5. PLAQUE RUPTURE AND THROMBUS FORMATION ADP Red blood cell Platelets Fibrin strands Fibrous cap Smooth muscle cells 11604 PLA99/069 h

  6. PLATELET THROMBUS 11604 PLA99/069 i

  7. Plaque rupture/fissure & thrombosis Fattystreak Atheromatousplaque Atheroscleroticplaque Normal Myocardial infarction Stroke Critical leg ischemia Cardiovascular death Clinically silent AnginaTransient ischemic attackClaudication/PAD Increasing Age ATHEROGENESIS AND ATHEROTHROMBOSIS: A PROGRESSIVE PROCESS 11604 PLA99/069 f

More Related