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This study by S. Misale et al. explores how KRAS amplification mediates resistance to cetuximab in DiFi cells. The research sheds light on acquired resistance mechanisms in cancer therapy, emphasizing the importance of understanding molecular changes for effective treatment strategies.
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KRAS amplification mediates acquired resistance to cetuximab in DiFi cells. S Misale et al. Nature000, 1-5 (2012) doi:10.1038/nature11156