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CK5/6

ER. CK5/6. Flat epithelial atypia. Columnar cell lesions: A spectrum: columnar cell change, columnar cell hyperplasia, flat epithelial atypia FEA has mild cytologic atypia (similar to ADH,DCIS) but without architectural atypia. May be more than one cell layer thick.

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CK5/6

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  1. ER CK5/6

  2. Flat epithelial atypia • Columnar cell lesions: • A spectrum: columnar cell change, columnar cell hyperplasia, flat epithelial atypia • FEA has mild cytologic atypia (similar to ADH,DCIS) but without architectural atypia. May be more than one cell layer thick. • Cytology: enlarged nuclei, rounding, crowding, loss of polarity, visible nucleoli, few mitoses.

  3. IHC in FEA • Not helpful • CCC, CCH, FEA, ADH, low grade DCIS all have the same immunophenotype • ER+, PgR+, HER2 -, E-Cadherin+, LMWK+, HMWK-.

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