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Classification of Chemo-Therapeutics

Classification of chemo-Therapeutics. 1- Anti-metabolites Cont.B- CYTIDINE ANALOGUES (Ara-C or cytosine arabinosides or cytarabine)Class: pyrimidine anti-metabolite Mechanism: mainly affect DNA synthesis. . . . PHOSPHORYLATION. . Ara-C TP inhibit DNA polymerase responsible for strand elongation

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Classification of Chemo-Therapeutics

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    1. Classification of Chemo-Therapeutics 1- Anti-metabolites Cell cycle phase specific Resemble naturally occuring metabolite as pyrimidine bases (C,G, u); purine bases (A,G) and folic acid Either form non functional DNA, or inhibit enzymes involved in DNA Synthesis A- Flourinated pyrimidines or pyrmidines anti-metabolites (5- FU) Class: pyrimidine anti-metabolite Mechanism: 5-FU (pro-drug) is a flourinated analogue of naturally occuring pyrimidine

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