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Protein synthesis

Protein synthesis. Central Dogma. If a segment of DNA is 5’-TACGATTAG-3’, the RNA that results from the transcription of this segment will be 3’-TAGGATTAU-5’ 3’-ATGCTAATA-5’ 3’-UACGAUUAG-5’ 3’-AACGAUUAA-5’ 3’-AUGCUAAUC-5’. Answer: e. binding. initiation. elongation. termination.

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Protein synthesis

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  1. Protein synthesis

  2. Central Dogma

  3. If a segment of DNA is 5’-TACGATTAG-3’, • the RNA that results from the transcription • of this segment will be • 3’-TAGGATTAU-5’ • 3’-ATGCTAATA-5’ • 3’-UACGAUUAG-5’ • 3’-AACGAUUAA-5’ • 3’-AUGCUAAUC-5’ Answer: e

  4. binding initiation elongation termination

  5. Ribozyme

  6. Translation

  7. tRNA

  8. P A

  9. Duplication mutation

  10. According to the Jacob-Monod model of the lac operon, the regulator gene does which of the following? a. Specifies the amino acid sequence of the enzyme. b. Controls the activity of histones. c. Determines whether promoter genes will be translated. d. Directs the synthesis of a repressor protein. e. Produces corepressor substances. Answer: d

  11. zinc-finger helix-turn-helix

  12. “Go” Mutation (1) Proto Oncogenes Oncogenes 2. “Stop” Mutation (2) Suppressor mutant genes suppressor 3. Genes that recognize DNA errors and repair or halt cell cycle (apoptosis) Repair Mutation (3) Genes abnormal repair genes Normal Genes Cancer Genes Mutation

  13. Examples of “cancer genes” • 1993- APC Suppressor Colon P53 Supressor Various • 1994 P16 Suppressor Melanoma • 1995 HNPCC Repair Colon AT Repair Various • 1996 HPC1 Oncogene Prostate BRCA1-2 Suppressor Breast • 1997 B-CAT Oncogene Colon PTEN Suppressor Brain Breast Colon • 1998 P73 Suppressor Nerve

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