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Protein synthesis - PowerPoint PPT Presentation


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Protein synthesis. Central Dogma. If a segment of DNA is 5’-TACGATTAG-3’, the RNA that results from the transcription of this segment will be 3’-TAGGATTAU-5’ 3’-ATGCTAATA-5’ 3’-UACGAUUAG-5’ 3’-AACGAUUAA-5’ 3’-AUGCUAAUC-5’. Answer: e. binding. initiation. elongation. termination.

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Protein synthesis


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Presentation Transcript
slide8

If a segment of DNA is 5’-TACGATTAG-3’,

  • the RNA that results from the transcription
  • of this segment will be
  • 3’-TAGGATTAU-5’
  • 3’-ATGCTAATA-5’
  • 3’-UACGAUUAG-5’
  • 3’-AACGAUUAA-5’
  • 3’-AUGCUAAUC-5’

Answer: e

slide9

binding

initiation

elongation

termination

slide15

P

A

slide26

According to the Jacob-Monod model of

the lac operon, the regulator gene does

which of the following?

a. Specifies the amino acid sequence of

the enzyme.

b. Controls the activity of histones.

c. Determines whether promoter genes

will be translated.

d. Directs the synthesis of a repressor

protein.

e. Produces corepressor substances.

Answer: d

slide31

zinc-finger

helix-turn-helix

slide34
“Go” Mutation (1)

Proto Oncogenes

Oncogenes

2. “Stop” Mutation (2)

Suppressor mutant

genes suppressor

3. Genes that recognize DNA errors and repair or halt cell cycle (apoptosis)

Repair Mutation (3)

Genes abnormal

repair

genes

Normal

Genes

Cancer

Genes

Mutation

examples of cancer genes
Examples of “cancer genes”
  • 1993- APC Suppressor Colon

P53 Supressor Various

  • 1994 P16 Suppressor Melanoma
  • 1995 HNPCC Repair Colon

AT Repair Various

  • 1996 HPC1 Oncogene Prostate

BRCA1-2 Suppressor Breast

  • 1997 B-CAT Oncogene Colon

PTEN Suppressor Brain

Breast

Colon

  • 1998 P73 Suppressor Nerve