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CHIKUNGUNYA VIROLOGIA Y PATOGENESIS

CHIKUNGUNYA VIROLOGIA Y PATOGENESIS. SOCIEDAD HONDUREÑA DE ENFERMEDADES INFECCIOSAS SHEI. Familia Togaviridae , genero Alphavirus. Origenes. Deriva de la raiz verbal Kimakonde , kungunyala que significa “ encorvado “

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CHIKUNGUNYA VIROLOGIA Y PATOGENESIS

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  1. CHIKUNGUNYA VIROLOGIA Y PATOGENESIS SOCIEDAD HONDUREÑA DE ENFERMEDADES INFECCIOSAS SHEI

  2. FamiliaTogaviridae, generoAlphavirus

  3. Origenes • Deriva de la raiz verbal Kimakonde, kungunyalaquesignifica “ encorvado “ • Desde Africa occidental hasta Archipielago de Filipinas

  4. Cepa viral de la epidemiaeuropea Mutacion en la Glicoproteina E-1 A226V • Mayor capacidad de infeccion y replicacion en A. albopictus

  5. 65 – 70 nms

  6. Celulasblanco de CHIKV • Epiteliales • Monocitos • Macrofagos • Endoteliales • Fibroblastos

  7. REPLICACION VIRAL

  8. Diseminacion del virus Viremia en la primerasemana 3,3x109

  9. Periodos de incubacionextrinseco e intrinseco del virus CHIK

  10. INFECCION DE FIBROBLASTOS EN LA CAPSULA ARTICULAR POR EL CHIKV

  11. Fibroblastosinfectados en dermis y en celulassatelitesmusculares

  12. Preguntasporcontestar y retos en investigacion • Identificacion de lasdeterminantesmolecularesquegobiernan el tropismocelular ? • Bases fisiopatologicas de los sintomascronicos: • Persistencia viral ? • Inmunopatologia? • Infeccion muscular • Relevancia del compromiso del SNC ? • Enfoqueterapeutico ? • Vacuna ?

  13. PREVENCIONLa mejorterapeutica

  14. GRACIAS

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