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Key Points

Key Points. LKB1 regulates cell polarity and functions as a haplo -insufficient tumor suppressor LKB1 activates the AMPK cascade to suppress growth and proliferation Loss of LKB1 enhances tumorigenesis as a secondary mutation.

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Key Points

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  1. Key Points • LKB1 regulates cell polarity and functions as a haplo-insufficient tumor suppressor • LKB1 activates the AMPK cascade to suppress growth and proliferation • Loss of LKB1 enhances tumorigenesis as a secondary mutation

  2. Peutz-Jeghers Syndrome leads to noncancerous growths called hamartomatous polyps in the gastrointestinal tract

  3. LKB1 encodes a serine/threonine kinase

  4. LKB1 is bound and activated by STRAD, inducingG1 cell cycle arrest

  5. AMPK is a master regulator of cellular energy homeostasis

  6. The LKB1/AMPK/TSC/mTORC1 Pathway is often mutated in Cancers

  7. LKB1 loss in Mice

  8. Works Cited • HuretJL . STK11 (serine/threonine kinase 11). Atlas Genet CytogenetOncolHaematol. February 2002 . • URL : http://AtlasGeneticsOncology.org/Genes/STK11ID292.html • Bapat B, Perera S . STK11 (serine/threonine kinase 11). Atlas Genet CytogenetOncolHaematol. January 2007 . • "AMPK Signaling." Cell Signaling Technology. Cell Signaling Technology, Inc, Apr. 2006. Web. 10 Apr. 2013. • Babineaux, M., Gabriel Lee, and Andrew W. DuPont. "Intussuception in Peutz-Jegher Syndrome." DAVE Project-Gastroenterology. Pentax Medical, 21 Jan. 2010. Web. 10 Apr. 2013. • Korsse, S. E., M. P. Peppelenbosch, and W. V. Veelen. "Targeting LKB1 Signaling in Cancer." ScienceDirect.com. Erasmus Medical University Center, Apr. 2013. Web. 10 Apr. 2013. • "Peutz-Jeghers Syndrome." Genetics Home Reference. US National Library of Medicine, 9 Feb. 2013. Web. 10 Apr. 2013. • Shaw, Reuben J., Katja A. Lamia, Debbie Vasquez, Seung-Hoi Koo, NabeelBardeesy, Ronald A. DePinho, Marc Montminy, and Lewis C. Cantley. "The Kinase LKB1 Mediates Glucose Homeostasis in Liver and Therapeutic Effects of Metformin." Science, 9 Dec. 2005. Web. 1 Apr. 2013. • "STK11." Serine/threonine Kinase 11. US National Library of Medicine, Aug. 2007. Web. 10 Apr. 2013. • Veelen, W. V., S. E. Korsse, L. V. Laar, and M. P. Peppelenbosch. "The Long and Winding Road to Rational Treatment of Cancer Associated with LKB1/AMPK/TSC/mTORC1 Signaling." Oncogene. Nature, 24 Jan. 2011. Web. 1 Apr. 2013. • Zeqiraj, E., BM Filippi, S. Goldie, I. Navratilova, J. Boudeau, M. Deak, D. R. Alessi, and D. M. Van Aalten. "ATP and MO25 Regulate the Conformational State of the STRAD Pseudokinase and Activation of the LKB1 Tumour Suppressor." PubMed.gov. US National Library of Medicine, 9 June 2009. Web. 1 Apr. 2013.

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