Shock in the pediatric patient or oxygen don t go where the blood won t flow
1 / 63

Shock in the Pediatric Patient: or Oxygen Don’t Go Where the Blood Won’t Flow! - PowerPoint PPT Presentation

  • Uploaded on

Shock in the Pediatric Patient: or Oxygen Don’t Go Where the Blood Won’t Flow!. James D. Fortenberry MD FAAP, FCCM Medical Director, PICU Division of Critical Care Medicine Children’s Healthcare of Atlanta. Objectives. Define shock and its different categories

I am the owner, or an agent authorized to act on behalf of the owner, of the copyrighted work described.
Download Presentation

PowerPoint Slideshow about 'Shock in the Pediatric Patient: or Oxygen Don’t Go Where the Blood Won’t Flow!' - bethan

An Image/Link below is provided (as is) to download presentation

Download Policy: Content on the Website is provided to you AS IS for your information and personal use and may not be sold / licensed / shared on other websites without getting consent from its author.While downloading, if for some reason you are not able to download a presentation, the publisher may have deleted the file from their server.

- - - - - - - - - - - - - - - - - - - - - - - - - - E N D - - - - - - - - - - - - - - - - - - - - - - - - - -
Presentation Transcript
Shock in the pediatric patient or oxygen don t go where the blood won t flow

Shock in the Pediatric Patient:orOxygen Don’t Go Where the Blood Won’t Flow!

James D. Fortenberry MD FAAP, FCCM

Medical Director, PICU

Division of Critical Care Medicine

Children’s Healthcare of Atlanta


  • Define shock and its different categories

  • Review basic physiologic aspects of shock

  • Describe management of shock including:

    • oxygen supply and demand

    • fluid resuscitation

      • crystalloid vs. colloid controversy

    • vasopressor support

Definition of shock
Definition of Shock

  • Uncontrolled blood or fluid loss

  • Blood pressure less than 5th percentile for age

  • Altered mental status, low urine output, poor capillary refill

  • None of the above

Definition of shock1

Definition of Shock

An acute complex pathophysiologic state of circulatory dysfunction which results in a failure of the organism to deliver sufficient amounts of oxygen and other nutrients to satisfy the requirements of tissue beds

Supply demand

Definition of shock2
Definition of Shock

  • Inadequate tissue perfusion to meet tissue demands

  • Usually result of inadequate blood flow and/or oxygen delivery

  • Shock is not a blood pressure diagnosis!!

Characteristics of shock
Characteristics of Shock

  • End organ dysfunction:

    • reduced urine output

    • altered mental status

    • poor peripheral perfusion

  • Metabolic dysfunction:

    • acidosis

    • altered metabolic demands

Essentials of life
Essentials of Life

  • Gas exchange capability of lungs

  • Hemoglobin

  • Oxygen content

  • Cardiac output

  • Tissues to utilize substrate

Arterial oxygen content
Arterial Oxygen Content

100 mm Hg

PaO2 100 mmHg

Partial Pressure

SaO2 97%

Oxygen Saturation


Hgb 15 gm/100 mL



O2 in plasma

O2 bound to Hgb

Oxygen delivery
Oxygen Delivery

DO2=Cardiac Output x 1.34 (Hgb x SaO2) + Pa02 x 0.003


Oxygen Express



Cardiac output

Cardiac Output

The volume of blood ejected by the heart in one minute

4 - 8 liters / minute

Cardiac output c o heart rate x stroke volume
Cardiac OutputC.O.=Heart Rate x Stroke Volume

  • Heart rate

  • Stroke volume:

    • Preload- volume of blood in ventricle

    • Afterload- resistance to contraction

    • Contractility- force applied

Cardiac output c o mean arterial pressure map cvp svr
Cardiac OutputC.O.=Mean arterial pressure (MAP) - CVP/SVR

  • To improve CO:

  • MAP

  • CVP

  • SVR





Heart Rate

Stroke Volume

Cardiac Output

O2 Content




O2 Delivery

Arterial Blood Pressure

Classification of shock


dehydration,burns, hemorrhage


septic, anaphylactic, spinal






organ perfusion is maintained


Circulatory failure with end organ dysfunction


Irreparable loss of essential organs

Classification of Shock

Hypovolemic shock

Hypovolemic Shock:

Inadequate Fluid Volume

(decreased preload)

Hypovolemic shock causes
Hypovolemic Shock:Causes

  • Fluid depletion

    • internal

    • external

  • Hemorrhage

    • internal

    • external

Cardiogenic shock

Cardiogenic Shock:

Pump Malfunction

(decreased contractility)

Cardiogenic shock causes
Cardiogenic Shock:Causes

Electrical Failure

  • Mechanical Failure

    • Cardiomyopathy

    • metabolic

    • anatomic

    • hypoxia/ischemia

Distributive shock

Distributive Shock

Abnormal Vessel Tone

(decreased afterload)

Distributive shock1

Distributive Shock


Venous Pooling

Decreased Preload

Maldistribution of regional blood flow

Distributive shock2
Distributive Shock:


  • Sepsis

  • Anaphylaxis

  • Neurogenesis (spinal)

  • Drug intoxication (TCA, calcium, Channel blocker)

Septic Shock

Decreased Pump Function

Decreased Volume

Abnormal Vessel Tone

Cardiac OutputC.O.=Heart Rate x Stroke Volume

  • Heart rate

  • Stroke volume:

    • Preload- volume of blood in ventricle

    • Afterload- resistance to contraction

    • Contractility- force applied

Clinical assessment
Clinical Assessment

  • Heart rate

  • Peripheral circulation

    • capillary refill

    • pulses

    • extremity temperature

  • Pulmonary

  • End organ perfusion

    • brain

    • kidney

Improving stroke volume therapy for cardiovascular support
Improving Stroke Volume:Therapy for Cardiovascular Support







Septic shock

Septic Shock

Early (“Warm”)

Decreased peripheral vascular resistance

Increased cardiac output

Late (“Cold”)

Increased peripheral vascular resistance

Decreased cardiac output

Obstructive shock



Obstructive shock causes
Obstructive Shock: AgeCauses

  • Pericardial tamponade

  • Pulmonary embolism

  • Pulmonary hypertension

Goals of resuscitation

O Age2 content

Cardiac output

Blood pressure

Goals of Resuscitation

  • Overall goal:

    • increase O2 delivery

    • decrease demand



Principles of management
Principles of Management Age

  • A: Airway

    • patent upper airway

  • B: Breathing

    • adequate ventilation and oxygenation

  • C: Circulation

    • optimize

      • cardiac function

      • oxygenation

Act quickly think slowly
Act quickly, AgeThink slowly.

Greek Proverb

Airway management
Airway Management Age

  • Patients in shock have:

    • O2 delivery

    • progressive respiratory fatigue/failure

    • energy shunted from vital organs

    • afterload

Airway management1
Airway Management Age

  • Early intubation provides:

    • O2 delivery and content

    • controlled ventilation which:

      • reduces metabolic demand

      • allows C.O. to vital organs

Therapy Age


Heart Rate


Fluid choices
Fluid Choices Age



Less Filling

Tastes Great !

Crystalloids hypotonic fluids d 5 1 4 ns
Crystalloids AgeHypotonic Fluids (D5 1/4 NS)

  • No role in resuscitation

  • Maintenance fluids only

Fluids fluids fluids
Fluids, Fluids, Fluids Age

  • Key to most resuscitative efforts

  • Give generously and reassess

Crystalloids isotonic fluids
Crystalloids AgeIsotonic Fluids

  • Intravascular volume expansion

  • Hauser:

    • crystalloids rapidly redistribute

  • Lethal animal model

    • NS = good resuscitative fluid

    • 4x blood volume to restore hemodynamics

Crystalloids isotonic fluids1
Crystalloids AgeIsotonic Fluids

  • 2 trauma studies

    • crystalloids = colloids but:

      • 4x amount

      • longer time to resuscitation

Crystalloids complications
Crystalloids AgeComplications

  • Under-resuscitation

    • renal failure

  • Over-resuscitation

    • pulmonary edema

    • peripheral edema

Crystalloids summary
Crystalloids AgeSummary

  • Crystalloids less effective than equal volume of colloids

  • Preferred when 1o deficit is water and/or electrolytes

  • Good in initial resuscitation to restore extracellular volume

  • Hypertonic solutions however, may act as plasma volume expanders

Oncotic pressure (tendency to pull unit) Age

Hydrostatic pressure (tendency to drive unit)

Fluid Transport


Colloids albumin
Colloids AgeAlbumin

  • Hepatic production

  • MW = 69,000

  • 80% of COP

  • Serum t1/2:

    18 hours endogenous

    16 hoursexogenous

Colloids hydroxyethyl starch hespan
Colloids AgeHydroxyethyl Starch (Hespan)

  • Synthetic

  • Derived from corn starch

  • Average MW = 69,000

  • Stable, nonantigenic

  • Used for volume expansion

  • Renal excretion

    • t 1/2 2-67 hours

    • 90% gone in 42 days

Colloids hydroxyethyl starch hespan1
Colloids AgeHydroxyethyl Starch (Hespan)

  • Greater in COP than albumin

  • Longer duration of action

  • 0.006% adverse reactions

  • No effect on blood typing

  • Prolongs PT, PTT and clotting times

  • Dosage

    • 20 ml/Kg/day

    • max 1500 ml/day

Fluid choices1
Fluid Choices Age

  • Based on:

    • type of deficit

    • urgency of repletion

    • pathophysiology of condition

    • plasma COP

Tastes Great !

Less Filling

Fluid choices2
Fluid Choices Age

  • Crystalloids for initial resuscitation

  • PRBC’s to replace blood loss

Fluid management in pediatric septic shock
Fluid Management in Pediatric Septic Shock Age

  • Emphasis on the golden hour

  • Early aggressive use of fluids may improve outcome

  • Titrate-Reassess!

Clinical Practice Parameters,

Carcillo et al., CCM, 2002

Alpha beta meter

Alpha-Beta Meter Age







Dopamine activity

Dopamine Activity Age

0.5-5.0 mcg/kg/min - dopaminergic receptors

2.0-10 mcg/kg/min - beta receptors (inotrope)

10-20 mcg/kg/min - alpha and beta receptors

Over 20 mcg/kg/min - alpha receptors (pressors)

A Rational Approach to Shock in the Pediatric Patient Age

Shock / Hypotension

Volume Resuscitation

Signs of adequate circulation

Adequate MAP

NO pressors



A Rational Approach to Pressor Use in the PICU

Signs of adequate circulation

Adequate MAP



Inadequate MAP

Dopamine and/or Norepinephrine

A Rational Approach to Pressor Use in the PICU

Dopamine and/or norepinephrine

adequate MAP

Dobutamine or Milrinone


Inadequate MAP

low C.O.




New therapies in septic shock
“New” Therapies in Septic Shock PICU

  • Steroids

  • Vasopressin

  • Activated Protein C (Xigris) in septic shock

Management of pediatric septic shock the golden hour
Management of Pediatric Septic Shock: The Golden Hour PICU

  • First 15 minutes

  • Emphasis on response to volume

Clinical Practice Parameters, Carcillo et al., CCM, 2002

Patients don t suddenly deteriorate healthcare professionals suddenly notice

Patients don’t suddenly deteriorate, healthcare professionals suddenly notice!