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Risk Assessment. How does one go about creating a Risk Assessment?. According to the EPA, risk assessments generally fall into two categories. Human Health Ecological. What is Human Health Risk Assessment?.

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Risk Assessment

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    1. Risk Assessment

    2. How does one go about creating a Risk Assessment?

    3. According to the EPA, risk assessments generally fall into two categories • Human Health • Ecological

    4. What is Human Health Risk Assessment? A human health risk assessment is the process to estimate the nature and probability of adverse health effects in humans who may be exposed to chemicals in contaminated environmental media, now or in the future.

    5. Step 1: Hazard Identification

    6. Key Components of Hazard Identification • A wide variety of studies and analysis are used to support a hazard identification analysis. • Toxicokinetics considers how the body absorbs, distributes, metabolizes, and eliminates specific chemicals. • Toxicodynamics focus on the effects that chemicals have on the human body. Models based on these studies can describe mechanisms by which a chemical may impact human health, thus providing insights into the possible effects of a chemical.

    7. Step 2: Dose-Response Assessment

    8. What is an acceptable dose? Almost 500 years ago Paracelsus (1493-1541) wrote: "Dosis facit venenum" or "the dose makes the poison." The relationship between dose and response (health effect) is still one of the most fundamental concepts of toxicology.

    9. How are acceptable doses defined? Dose-response assessment is a two-step process. The first step is an assessment of all data that are available or can be gathered through experiments, in order to document the dose-response relationship(s) over the range of observed doses (i.e, the doses that are reported in the data collected). The second step consists of extrapolation to estimate the risk (probably of adverse effect) beyond the lower range of available observed data in order to make inferences about the critical region where the dose level begins to cause the adverse effect in the human population.

    10. Why does EPA evaluate whether children may be at greater health risks than adults? • their bodily systems are developing; • they eat more, drink more, and breathe more in proportion to their body size; and • their behavior, such as crawling and hand-to-mouth activity, can expose them more to chemicals and microorganisms. In light of what is now known about the greater susceptibility early in life to some stressors, Executive Order 13045 -- Protection of Children from Environmental Health Risks and Safety Risks -- was issued in 1997.

    11. Step 3 - Exposure Assessment

    12. Quantifying Exposure. There are three basic approaches for quantifying exposure. Each approach is based on different data, and has different strengths and weaknesses; using the approaches in combination can greatly strengthen the credibility of an exposure risk assessment. • Point of Contact Measurement - The exposure can be measured at the point of contact (the outer boundary of the body) while it is taking place, measuring both exposure concentration and time of contact, then integrating them; • Scenario Evaluation - The exposure can be estimated by separately evaluating the exposure concentration and the time of contact, then combining this information; • Reconstruction - the exposure can be estimated from dose, which in turn can be reconstructed through internal indicators (biomarkers, body burden, excretion levels, etc) after the exposure has taken place (reconstruction).

    13. Step 4 - Risk Characterization

    14. Principles of Conducting Risk Characterizations • A good risk characterization will restate the scope of the assessment, express results clearly, articulate major assumptions and uncertainties, identify reasonable alternative interpretations, and separate scientific conclusions from policy judgments. EPA's Risk Characterization Policy calls for conducting risk characterizations in a manner that is consistent with the following principles: • Transparency • Clarity • Consistency • Reasonability

    15. Transparency - The characterization should fully and explicitly disclose the risk assessment methods, default assumptions, logic, rationale, extrapolations, uncertainties, and overall strength of each step in the assessment.

    16. Clarity - The products from the risk assessment should be readily understood by readers inside and outside of the risk assessment process. Documents should be concise, free of jargon, and should use understandable tables, graphs, and equations as needed.

    17. Consistency - The risk assessment should be conducted and presented in a manner which is consistent with EPA policy, and consistent with other risk characterizations of similar scope prepared across programs within the EPA.

    18. Reasonability - The risk assessment should be based on sound judgment, with methods and assumptions consistent with the current state-of-the-science and conveyed in a manner that is complete and balanced, informative.

    19. Ecological Risk Assessment

    20. How Does EPA Conduct an Ecological Risk Assessment? • Planning - Planning and Scoping process • Phase 1 -Problem formulation • Phase 2 - Analysis • Phase 3 -Risk characterization

    21. Phase 1 - Problem Formulation: Define an assessment endpoint to determine what ecological entity is important to protect.

    22. What is an ecological entity? • A species (for instance: piping plover) • A functional group of species (for instance: piscivores - i.e., fish eaters) • A community (for instance: benthic invertebrates) • An ecosystem (for instance: lake) • A specific valued habitat (for instance: wet meadows) • Another entity of concern

    23. Phase 2 - Analysis The goal of the analysis phase is to provide the ingredients necessary for determining or predicting ecological responses to stressors under exposure conditions of interest.

    24. A proper analysis would include: • Area use: the proportion of the site that is in the area an animal typically uses during normal activities (home range); OR the proportion of an animal’s home range that is within a site; • Food ingestion rate: how much food is consumed by an animal over a specific period of time (typically, one day); • Bioaccumulation rates: the process by which chemicals are taken up by a plant or animal either directly from exposure to a contaminated medium (soil, sediment, water) or by eating food containing the chemical; • Bioavailability: how easily a plant or animal can take up a particular contaminant from the environment; • Life stage: juvenile, adult, etc.

    25. Phase 3 - Risk Characterization Risk Characterization is the final phase of an ecological risk assessment. It is the culmination of all work done during the previous phases.

    26. So, what is Risk Assessment? What do you think?

    27. Images courtesy of: http://www.scienceinthebox.com/en_UK/safety/riskasshuman_en.html http://www.epa.gov/risk_assessment http://www.spa.usace.army.mil/recreation/jm/index.htm http://www.tripadvisor.com/LocationPhotos-g147293-d320656-Indigenous_Eyes_Ecological_Park-Punta_Cana_Dominican_Republic.html http://savethehousatonic.org/?page_id=62 http://water.epa.gov/polwaste/nps/acid_mne.cfm http://www.goldsim.com/Web/Solutions/EnvironmentalSystems/HumanHealthRisk/ http://www.dtcc.com/news/newsletters/dtcc/2011/mar/dtcc_calls.php http://johnnygoodtimes.com/2008/02/the-donspiracist-returns-with-fluoride-poison-without-consent/ http://dodd.cmcvellore.ac.in/hom/11%20-%20Paracelsus.html http://www.positive-thinking-for-you.com/consistency.html http://icanhascheezburger.com/2009/01/17/funny-pictures-tried-being-reasonable/ http://www.CartoonStock.com http://simpsons.wikia.com/wiki/Multi-Eyed_Squirrel