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Blood

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  1. Blood

  2. Components of Blood • Whole blood • RBCs • WBCs • Platelets: cell fragments that aid in clotting • Plasma • 90% water (allows materials to dissolve) • Amino acids, glucose, hormones, vitamins, salts, waste • Concentrations allows diffusion in/out of blood stream

  3. Click picture to play

  4. Red Blood Cells • Produced from stem cells in bone marrow • Lose nucleus as they mature • Transport O2 to cells; remove CO2 • O2 binds to hemoglobin proteins • Dead cells filtered by liver & spleen

  5. Sickle Cell Normal

  6. White Blood Cells • Remove foreign invaders & dead cells • Able to move through body tissue

  7. Platelets • Form clots when bleeding • Proteins form a web to trap cells & platelets

  8. ABO Blood Groups • Proteins on blood cells determine blood type • Antigen (markers) • proteins on cell’s surface that identify cells as foreign or natural • Antibodies: • proteins from B cells to attack invaders • Float freely in plasma

  9. Group A blood • A antigens on the surface of your RBCs • B antibodies in your blood plasma

  10. Group B blood • B antigens on the surface of your RBCs • A antibodies in your blood plasma

  11. Group AB blood • Both A and B antigens on the surface of your RBCs • Neither A or B antibodies in your blood plasma

  12. Group O blood • Neither A or B antigens on the surface of your RBCs • Both A and B antibodies in your blood plasma

  13. If you have type A blood, can you receive: Type B blood from a donor? Type AB blood from a donor? Type O blood from a donor?

  14. If you have type B blood, can you receive: Type A blood from a donor? Type AB blood from a donor? Type O blood from a donor?

  15. If you have type AB blood, can you receive: Type A blood from a donor? Type B blood from a donor? Type O blood from a donor?

  16. If you have type O blood, can you receive: Type A blood from a donor? Type B blood from a donor? Type AB blood from a donor?

  17. Rh Factors • If Rh+ • Protein found in blood • Can receive Rh+ or Rh- blood • If Rh- • Lack protein in blood • Only receive Rh- blood

  18. Francis was just in a bad accident and lost a lot of blood. He is blood type B+. Can you help save him?

  19. Blood type B+ Antigens: Which does he have? A B Rh Antibodies: Which does he have? A B Rh

  20. B+ B antigens Rh antigens B+ B antigens Rh antigens B+ B antigens Rh antigens This person has B+ blood type because of the B and Rh antigensCan he accept B+ blood? Yes. The A antibodies will not attack. Therefore, no clumping of blood cells will occur. Vein B+ B antigens Rh antigens A antibody B+ B antigens Rh antigens A antibody B+ B antigens Rh antigens A antibody

  21. B- B antigens B- B antigens B- B antigens This person has B+ blood type because of the B and Rh antigensCan he accept B- blood? Yes. The A antibodies will not attack. Therefore, no clumping of blood cells will occur. Vein B+ B antigens Rh antigens A antibody B+ B antigens Rh antigens A antibody B+ B antigens Rh antigens A antibody

  22. A+ A antigens Rh antigens A+ A antigens Rh antigens A+ A antigens Rh antigens This person has B+ blood type because of the B and Rh antigensCan he accept A+ blood? No. The A antibodies will attack the A antigens. This will cause the blood cells to clump, thus stopping blood flow. This person may die. Vein B+ B antigens Rh antigens A antibody B+ B antigens Rh antigens A antibody B+ B antigens Rh antigens A antibody

  23. A- A antigens A- A antigens A- A antigens This person has B+ blood type because of the B and Rh antigensCan he accept A- blood? No. The A antibodies will attack the A antigens. This will cause the blood cells to clump, thus stopping blood flow. This person may die. Vein B+ B antigens Rh antigens A antibody B+ B antigens Rh antigens A antibody B+ B antigens Rh antigens A antibody

  24. AB+ A antigens B antigens Rh antigens AB+ A antigens B antigens Rh antigens AB+ A antigens B antigens Rh antigens This person has B+ blood type because of the B and Rh antigensCan he accept AB+ blood? No. The A antibodies will attack the A antigens. This will cause the blood cells to clump, thus stopping blood flow. This person may die. Vein B+ B antigens Rh antigens A antibody B+ B antigens Rh antigens A antibody B+ B antigens Rh antigens A antibody

  25. AB- A antigens B antigens AB- A antigens B antigens AB- A antigens B antigens This person has B+ blood type because of the B and Rh antigensCan he accept AB- blood? No. The A antibodies will attack the A antigens. This will cause the blood cells to clump, thus stopping blood flow. This person may die. Vein B+ B antigens Rh antigens A antibody B+ B antigens Rh antigens A antibody B+ B antigens Rh antigens A antibody

  26. O+ Rh antigens O+ Rh antigens O+ Rh antigens This person has B+ blood type because of the B and Rh antigensCan he accept O+ blood? Yes. The A antibodies won’t attack. Therefore, no clumping of blood cells will occur. Vein B+ B antigens Rh antigens A antibody B+ B antigens Rh antigens A antibody B+ B antigens Rh antigens A antibody

  27. O- No antigens O- No antigens O- No antigens This person has B+ blood type because of the B and Rh antigensCan he accept O- blood? Yes. The A antibodies will not attack. Therefore, no clumping of blood cells will occur. Vein B+ B antigens Rh antigens A antibody B+ B antigens Rh antigens A antibody B+ B antigens Rh antigens A antibody

  28. Sebastian was just involved in an accident at work and lost a lot of blood. He is blood type A-. Can you help save him?

  29. Blood type A- Antigens: Which does he have? A B Rh Antibodies: Which does he have? A B Rh

  30. A- A antigens A- A antigens A- A antigens This person has A- blood type because of the A antigenCan he accept A- blood? Yes. The B and Rh antibodies will not attack. Therefore, no clumping of blood cells will occur. A- A antigens Rh antibody B antibody A- A antigens A- A antigens Rh antibody B antibody

  31. A+ A antigens Rh antigens A+ A antigens Rh antigens A+ A antigens Rh antigens This person has A- blood type because of the A antigenCan he accept A+ blood? No. The Rh antibodies will attack the Rh antigens. This will cause the blood cells to clump, thus stopping blood flow. This person may die. A- A antigens Rh antibody B antibody A- A antigens A- A antigens Rh antibody B antibody

  32. B- B antigens B- B antigens B- B antigens This person has A- blood type because of the A antigenCan he accept B- blood? No. The B antibodies will attack the B antigens. This will cause the blood cells to clump, thus stopping blood flow. This person may die. A- A antigens Rh antibody B antibody A- A antigens A- A antigens Rh antibody B antibody

  33. B+ B antigens Rh antigens B+ B antigens Rh antigens B+ B antigens Rh antigens This person has A- blood type because of the A antigenCan he accept B+ blood? No. Both B and Rh antibodies will attack the B and Rh antigens. This will cause the blood cells to clump, thus stopping blood flow. This person may die. A- A antigens Rh antibody B antibody A- A antigens A- A antigens Rh antibody B antibody

  34. AB- A antigens B antigen AB- A antigens B antigen AB- A antigens B antigen This person has A- blood type because of the A antigenCan he accept AB- blood? No. The B antibodies will attack the B antigens. This will cause the blood cells to clump, thus stopping blood flow. This person may die. A- A antigens Rh antibody B antibody A- A antigens A- A antigens Rh antibody B antibody

  35. AB+ A antigens B antigens Rh antigens AB+ A antigens B antigens Rh antigens AB+ A antigens B antigens Rh antigens This person has A- blood type because of the A antigenCan he accept AB+ blood? No. Both B and Rh antibodies will attack the B and Rh antigens. This will cause the blood cells to clump, thus stopping blood flow. This person may die. A- A antigens B antibody Rh antibody A- A antigens A- A antigens Rh antibody B antibody

  36. O- No antigens O- No antigens O- No antigens This person has A- blood type because of the A antigenCan he accept O- blood? Yes. The antibodies will not attack. Therefore, no clumping of blood cells will occur. A- A antigens B antibody Rh antibody A- A antigens A- A antigens Rh antibody B antibody

  37. O+ Rh antigens O+ Rh antigens O+ Rh antigens This person has A- blood type because of the A antigenCan he accept O+ blood? Yes. The antibodies will not attack. Therefore, no clumping of blood cells will occur. A- A antigens B antibody Rh antibody A- A antigens A- A antigens Rh antibody B antibody

  38. Blood type AB+ Antigens: Which does they have? A B Rh Antibodies: Which does they have? A B Rh

  39. Blood type O+ Antigens: Which does they have? A B Rh Antibodies: Which does they have? A B Rh

  40. Blood type AB- Antigens: Which does they have? A B Rh Antibodies: Which does they have? A B Rh

  41. Blood type B+ Antigens: Which does they have? A B Rh Antibodies: Which does they have? A B Rh

  42. Blood type O- Antigens: Which does they have? A B Rh Antibodies: Which does they have? A B Rh

  43. Can this work? • Acceptor 1. O- 2. A+ 3. AB- • Donor • AB- • 2. A- • 3. B-

  44. 1) Can this work? • Acceptor O- • Donor • AB- No! The AB antibodies attack the donors blood. Blood type O can only receive Blood type O.

  45. 2) Can this work? • Acceptor A+ • Donor • A- Yes! There are no Rh antigens on the donors blood cells.

  46. 3) Can this work? • Acceptor AB- • Donor • B- Yes! The AB patients can receive any blood type. And, both people do not have Rh antibodies.

  47. Kobe Kuiz • What are the components found inside blood? • What are the ingredients of plasma? • What is the purpose/function of RBCs? • Which part of blood stop bleeding when cut? • What do antibodies bind with? • If a person has type AB-, which antigens do they possess? Which antibodies? • If a person has type O+, which antigens do they possess? Which antibodies? • If a person is type A-, list all the blood types this person can receive in a transfusion. • If a person is type O-, list all the blood types this person can receive in a transfusion.