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Salicylic Acid Semisolid Preparations. Faith White Advisors: Dr. Antoine Al-Achi & Mrs. Janice Jackson-Freeman. Objective. The purpose of this experiment was to determine the distribution of salicylic acid in creams, ointments, and pastes. Key Terms. Salicylic Acid Cream Ointment

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salicylic acid semisolid preparations

Salicylic Acid Semisolid Preparations

Faith White

Advisors: Dr. Antoine Al-Achi

&

Mrs. Janice Jackson-Freeman

objective
Objective

The purpose of this experiment was to determine the distribution of salicylic acid in creams, ointments, and pastes.

key terms
Key Terms
  • Salicylic Acid
  • Cream
  • Ointment
  • Paste
salicylic acid c 7 h 6 o 3

Salicylic acid is a fine, white powder. It is used externally on the skin. It helps in the treatment of athlete’s foot, ringworm of the scalp, and the removal of warts, corns, and calluses. Salicylic acid is also incorporated into preparations for the treatment of acne, dandruff, seborrhea, and insect bites.

COOH

OH

Salicylic Acid(C7H6O3)
cream
Cream
  • Viscous liquid or semisolid emulsions of either the oil/water(o/w) or water/oil (w/o) type.

Examples:

  • O/W type:shaving, hand, and foundation creams
  • W/O type: cold and emollient creams
methods 1 preparation of cream
Methods1. Preparation of Cream

*Dissolve together using a steam bath till at the temperature of 70oC remove from heat, then immediately add salicylic acid.

+Dissolve together using a steam bath till at the temperature of 70oC.

-After both mixtures are at appropriate temperatures add together stirring rapidly and continuously until it has congealed.

ointment
Ointment
  • Semisolid preparations intended for the external application to the skin or mucous membranes; usually contain medicinal substances; properties vary.
methods 2 preparation of ointment
Methods2.Preparation of Ointment

^Dissolve together using a steam bath till at the temperature of 75oC remove from heat, then immediately add salicylic acid

#Dissolve together using a steam bath till at the temperature of 75oC.

-after both mixtures are at the appropriate temperatures add together stirring rapidly and continuously until it has congealed.

paste
Paste
  • Concentrates of absorptive powders dispersed (usually) in petrolatum or hydrophilic petrolatum. Often used in the treatment of oozing lesions. Are also used to restrict the area of treatment by acting as an absorbent.
methods 3 preparation of paste
Methods3.Preparation of Paste

#Mix the ingredients together in a mortar and pestle, then add salicylic acid to mixture and then mix in the white petrolatum.

preparation of diluted alcohol
Preparation of Diluted Alcohol
  • 515 mL of 95% ethyl alcohol USP was measured using volumetric flask and graduated cylinder.
  • 500 mL of deionized water was measured using volumetric flask.
  • Ethyl alcohol and deionized water was combined for a 49% alcohol solution.
preparation of 0 1 n sodium hydroxide
Preparation of 0.1 N Sodium Hydroxide
  • 8 grams of sodium hydroxide pellets was weighed and dissolved in deionized water and filled to 2 L mark on volumetric flask.
methods
Methods

a. To 25 mL of diluted alcohol (49%), one drop of phenolphthalein TS and sufficient 0.1 N sodium hydroxide from a buret was used to produce a faint pink color.

slide15

Methods

b. Five grams from one preparation was added and mixed for five minutes at 300 rpms on a stir plate.

c after the five minutes was up the liquid in the flask was clear or white
c. After the five minutes was up, the liquid in the flask was clear or white.

Methods

slide17

Methods

d. Drops of 0.1 N sodium hydroxide from a buret was added to the flask slowly till a faint pink color developed.

slide18

Methods

e. The amount of 0.1 N sodium hydroxide used was recorded to determine the precision.

amount of salicylic acid in dosage forms
Amount of Salicylic Acid in Dosage Forms

Each mL of 0.1 N sodium hydroxide is equivalent to 13.81 mg of salicylic acid.

conclusion

Conclusion

Due to inconsistencies in the data it was concluded that maybe there was not sufficient mixing time for the release of salicylic acid from the base...

acknowledgements
Acknowledgements

I would like to thank Dr. Al-Achi for all of his help in completing this experiment and Mrs. Freeman for all of her guidance, time, and patience.