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Typical cytokines secreted by types of CD4 T cells

IL-6, IL-17, IL-22. TGF-b, IL-10, +/- IL-4. IL-2, IFN-g, TNF-alpha, TNF-beta (a.k.a: LT-alpha). IL-4, IL-5, IL-6, IL-10, IL-13. Typical cytokines secreted by types of CD4 T cells. Notable TFs RORgT FOXP3 (some T regs) STAT1, T-bet, STAT4 STAT6, GATA3. Th17. Reg. CD4 T cell.

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Typical cytokines secreted by types of CD4 T cells

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  1. IL-6, IL-17, IL-22 TGF-b, IL-10, +/- IL-4 IL-2, IFN-g, TNF-alpha, TNF-beta (a.k.a: LT-alpha) IL-4, IL-5, IL-6, IL-10, IL-13 Typical cytokines secreted by types of CD4 T cells Notable TFs RORgT FOXP3 (some T regs) STAT1, T-bet, STAT4 STAT6, GATA3 Th17 Reg. CD4 T cell Th1 Th2 1

  2. Th17 Overview of Th0 differentiation High IL-6, IL-23, TGF-beta CD25 CD4 T cell Tr1 or Th3 TGF-beta Low IL-6, IL-23 Low IFN-g & IL-4 IL-10 Th0 High IFN-g or IL-4 Th1 Th2 High IFN-g, IL-12 High IL-4 2

  3. Cross-talk among CD4 T cell subsets Macrophage (impaired activation of other CD4 T cell subsets) IL-10 (-) T reg. TGF-b (-) Th1 IFN-g (-) TGF-b (-) Th17 IFN-g (-) IL-4 (-) Th2 IL-10 (-) Dendritic cell (decr. IL-12, decr. Th1 activation) [(-) = suppresses] 3

  4. CLASSICAL PATHWAY: • Ig + C1 ---> Ig-C1 • C1 esterase activity • C4 ------------------------------> C4b + C4a • C2 ------------------------------> C2b + C2a • C4b + C2a ---> C4b2a • C4b2a • C3 ---------------------------------> C3b + C3a • C4b2a + C3b ---> C4b2a3b • ALTERNATE PATHWAY: • C3 -------> C3b + C3a (spontaneous) • C3b + B ---> C3bB • D • C3bB --------------------> C3bBb + Ba • C3bBb + P ---> C3bBbP [Note: P = Properdin] • C3bBbP • C3 --------------------------------> C3b + C3a • C3bBb + C3b ---> C3bBb3b (a.k.a.: C3b2Bb) • SHARED COMPONENTS: • C5 convertase • C5 -----------------------------------------------> C5b + C5a • C5b + C6 + C7 + C8 + C9 ==> MAC 4

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