skeletal muscle physiology n.
Download
Skip this Video
Loading SlideShow in 5 Seconds..
SKELETAL MUSCLE PHYSIOLOGY PowerPoint Presentation
Download Presentation
SKELETAL MUSCLE PHYSIOLOGY

Loading in 2 Seconds...

play fullscreen
1 / 94

SKELETAL MUSCLE PHYSIOLOGY - PowerPoint PPT Presentation


  • 278 Views
  • Uploaded on

SKELETAL MUSCLE PHYSIOLOGY. Abraham D. Lee, Ph.D.,P.T. Department of Physical Therapy Office: Collier Building # 4206 Phone #: 419-383-3437 Email: abraham.lee2@utoledo.edu. Contents. 1. Muscle structure & organization 2. Muscle fiber type 3. Muscle action 4. Muscle mechanics

loader
I am the owner, or an agent authorized to act on behalf of the owner, of the copyrighted work described.
capcha
Download Presentation

SKELETAL MUSCLE PHYSIOLOGY


An Image/Link below is provided (as is) to download presentation

Download Policy: Content on the Website is provided to you AS IS for your information and personal use and may not be sold / licensed / shared on other websites without getting consent from its author.While downloading, if for some reason you are not able to download a presentation, the publisher may have deleted the file from their server.


- - - - - - - - - - - - - - - - - - - - - - - - - - E N D - - - - - - - - - - - - - - - - - - - - - - - - - -
    Presentation Transcript
    1. SKELETAL MUSCLE PHYSIOLOGY Abraham D. Lee, Ph.D.,P.T. Department of Physical Therapy Office: Collier Building # 4206 Phone #: 419-383-3437 Email: abraham.lee2@utoledo.edu

    2. Contents 1. Muscle structure & organization 2. Muscle fiber type 3. Muscle action 4. Muscle mechanics 5. Motor unit and its recruitment 6. Local muscle control 7. Muscle plasticity 8. Summary

    3. Muscle organization • Epimysium: wraps an entire muscle • Perimysium: wraps a bundle of muscle fibers. This bundle is called fascicle or fasciculus • Endomysium: wraps an individual muscle fiber • Sarcolemma: muscle membrane • Myofibrils: contractile filaments

    4. Myofibrils • Thin filament • Actin filaments • Troponin • Tropomyosin • Thick filament • Myosin: 4 light chains and 2 heavy chains • Heavy chains • Myosin head region: heavy meromyosin • Myosin tail region: light memromysin

    5. Muscle pennation • Longitudinal (non-pennated) architecture: muscle fibers in parallel to the muscle force generating axis • Example: biceps brachii, sartorius muscle • In these muscles fibers are said to be fusiform or spindle shaped. • “Pennate” architecture: muscle fibers are oriented at an angle or multiple angles relative to force-generating axis. • Unipennate: soleus-25 degree; vastus medialis-5 degree • Bipennate: gastrocnemius, rectus femoris • Multipennate: deltoid

    6. Effect of pennation Force loss Space saving

    7. Comparison b/n non-pennated & pennated muscle • Contraction • Fiber packing • w/ given volume • Force loss due • to pennation • # fiber • Muscle force • Production • CSA Non-pennatedPennated Fast Slow Less More No Yes Less More Less Greater Less Greater

    8. Muscle Fiber Type

    9. Muscle fiber type • Type I, • Slow-oxidative (SO) fibers • Type IIa, • Fast-oxidative-glycolytic (FOG) fibers • Type IIb, • Fast-glycolytic (FG) fibers

    10. Characteristics of different fibers #Mitochondria Resistance to fatigue Energy ATPase activity Vmax Efficiency • Type I Type IIa Type IIb • H H/M L • H H/M L • A A+AN AN • L H HH • L H HH • H M L L: low H: high M: moderate A: aerobic AN: anaerobic HH: highest

    11. Muscle composition in athletes % Type I %Type IIa &IIb 70-80 20-30 25-30 70-75 45-55 45-55 47-53 47-53 Distance runners Track sprinters Weight lifters Non-athletes Will fiber type change with training?

    12. Muscle Action • Excitation-contraction coupling • Type of muscle action

    13. Excitation-Contraction Coupling • Nerve impulse generation and propagation • Neuromuscular junction transmission • Muscle action potential propagation • Ca2+ release from SR • Ca2+ binding to troponin • Interaction of myosin head and actin • Cross bridge moves: tension development • Ca2+ taken up to SR • Ca2+ removal from troponin • Relaxation

    14. E-C coupling DHPR: dihydropyridine receptors RyR: ryanodine receptor Other possible mechanism: Inositol 1,4,5-triphosphate (InsP3) InsP3 receptor activation Ca2+ release from SR May play a role in slow twitch muscle in developmental stage (Talon et al., Am. J. Physiol 282: R1164-R1173, 2002)

    15. E-C coupling

    16. Sliding Filament Theory

    17. Changes during shortening muscle action • Sarcomere length (distance between two adjacent Z lines): shortens • A band: no change • I band: shortens • H zone: shortens

    18. Different type of muscle action (contraction) • Isometric action • Isotonic action (dynamic action) • Concentric action • Eccentric action

    19. Muscle mechanics It deals with how muscle force is generated and regulated.

    20. Factors that affect muscle force generation • Rate of muscle stimulation • Muscle length • Joint angle • Speed of action (speed of contraction) • Muscle fiber type • # of MU recruitment

    21. Rate of Muscle Stimulation • Twitch: • Tetanus:

    22. Muscle twitch

    23. Muscle tetanus

    24. Effect of Muscle Length

    25. Force-Length Relationship • Isolated muscle • In vivo human muscles

    26. Force-Length Relationship • Isolated muscle

    27. Force-Length Relationship • In vivo human muscles • Two things are considered: muscle length and joint angle • In general, a group of muscles produces more force (torque) when muscles are lengthened before contraction. But some muscles do not follow this rule.

    28. Shoulder muscles Shoulder flexors (anterior deltoid): causes to flex shoulder joint Shoulder extensors(posterior deltoid): causes to extend shoulder joint 180° 135° 90° 45° 40° 0°

    29. Knee flexors • A person is lying on the stomach (prone position) 90° 120° 45° 0° Trunk Lower leg Thigh Knee joint Hip joint Knee flexors (hamstring muscles): causes to flex knee joint

    30. Hip flexors • A person is lying on the back (supine position) 90° 120° 45° 0° Lower leg Thigh Trunk Knee joint hip joint Hip flexors (iliopsoas, sartorius): causes to flex hip joint

    31. Knee extensors • A person is sitting on the bench 0° 45° 120° 90° Knee extensors (quadriceps muscles): causes to extend knee joint

    32. Elbow flexors Elbow flexors (biceps brachii): causes to flex elbow joint

    33. Force arm distance

    34. Effect of Velocity (Speed of Action)

    35. Force-velocity curve

    36. Effect of Muscle Fiber

    37. Effectof muscle fiber type on force

    38. Muscle Power Need to consider two factors: 1. Muscle force 2. Speed of action