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Module 7- Respiratory System Pharmacology

Module 7- Respiratory System Pharmacology

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Module 7- Respiratory System Pharmacology

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  1. Module 7 PharmacologyRebecca Moriero

  2. Ventolin • Other names: Salbutamol • Brand Names: • Accuneb • ProairHFA • Proventil HFA • Albuterol • It is a β2-adrenergic agonists. These medications have a direct effect on the smooth muscle tissue of the bronchi, inhibiting the migration of smooth muscle (HASM) cells. • Type: Bronchodilators

  3. Ventolin • This medication is used for the relief of bronchospasm in conditions such as asthma and chronic obstructive pulmonary disease . It is fast acting because it is administered by inhalation for a direct effect on the smooth muscle of the bronchi.

  4. Ventolin • This medication comes as a liquid. Using a nebulizer (a machine that turns the liquid into a mist) in can be inhaled through the mouth. • Use: • When used to treat or prevent symptoms of lung disease, it needs to be inhaled every 4-6 hours. • To prevent difficulty breathing, it needs to be inhaled 15-30 minutes prior to workouts. • The nebulizer solution is usually used 3 to 4 times per day.

  5. Ventolin How it works: Oxygen and carbon dioxide travel through the bronchi as we breathe. People with asthma and COPD experience inflammation due to migration of HASM cells. The effect of this inflammation is a tighter space for air to travel and therefore difficulty breathing. O2 CO2

  6. Ventolin When ventolin is inhaled, the smooth muscles will relax and allow the bronchi to dilate. This will cause the inflammation to go down and restore normal breathing. O2 CO2

  7. Mucomyst • Other Names: Acetylcysteine • A derivative of cysteine (a semi-essential amino acid that can be synthesized by humans) has the ability to break disulfide bonds in mucus. When these bonds are dissolved, mucus is easier to cough up because it has been liquefied. • Type: Mucokinetic

  8. Mucomyst • This medication is used to help persons who are suffering from emphysema, pneumonia, cystic fibrosis, and other lung problems breathe better. This is done by thinning or dissolving thick lung mucus. • This medication comes in a liquid form. It may be given through a nebulizer, given through a face mask or placed in the air inside a plastic tent placed around the patient’s head.

  9. Mucomyst How it works: • As mucus production is increased and/or mucus begins to thicken and accumulate it results in difficulty breathing. Bronchi Mucus increases

  10. Mucomyst • As the mucolytic agent begins to break the disulfide bonds, mucus is liquefied and easier to cough up. This results in Increased air flow for breathing. Bronchi Mucus decreases

  11. Allegra • Other names: Fexofenadine • Brand Names: • Allegra • Fexidine • Telfast • Fastofen • Tilfur • Vifas • Telfexo • Allerfexo • It is an antihistamine drug used in the treatment of allergy symptoms. Its mechanism of action occurs by binding of the receptor antagonist of histamine H1.1 • Type: Antihistamine

  12. Allegra • Fexofenadine is used to treat allergy symptoms such as sneezing, watery eyes and runny nose. It works by blocking histamine. Histamine is a substance, produced by the human body, that produce allergy symptoms. • Fexofenadine comes as a tablet and a liquid suspension taken by mouth. Is used to treat allergy symptoms such as sneezing, watery eyes and runny nose.

  13. Allegra How it works: • Mast cells found in the respiratory and digestive systems release histamine when exposed to even a small amount of an allergen. Histamines bind to receptors of nearby cells that through interactions cause nearby blood vessels and secrete excess fluid because of swelling. Histamine Cell Wall Receptor Allergens enter

  14. Allegra • Fexofenadine binds to those receptors and prevents histamines from binding to them. With diminished availability of receptor sites for histamines, the signals that caused symptoms stop. This results in diminishing or eliminating the symptoms. Histamine has no binding site Antihistamine Cell Wall Receptor

  15. Sources • Albuterol Oral Inhalation • http://www.nlm.nih.gov/medlineplus/druginfo/meds/a682145.html • β2-adrenergic receptor agonists modulate human airway smooth muscle cell migration via vasodilator-stimulated phosphoprotein. • http://www.ncbi.nlm.nih.gov/pubmed/22210825 • FLONASE® • http://www.rxlist.com/flonase-drug.htm • Acetylcysteine (By breathing) • http://www.ncbi.nlm.nih.gov/pubmedhealth/PMHT0008809/?report=details • Acetylcysteine Solution • http://www.rxlist.com/acetylcysteine-solution-drug/indications-dosage.htm • acetylcysteine (Rx) - N-acetylcysteine, Mucomyst • http://reference.medscape.com/drug/n-acetylcysteine-mucomyst-acetylcysteine-343425#10 • Fexofenadine • http://www.nlm.nih.gov/medlineplus/druginfo/meds/a697035.html • Allegra • http://www.rxlist.com/allegra-drug/side-effects-interactions.htm • Antihistamine • https://www.youtube.com/watch?v=vCWV4AY5ulc

  16. Module 7 PharmacologyRebecca Moriero

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