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Pharmacology Summary notes

4MedStudents.com. Pharmacology Summary notes . Unit 9. R.E.A. 2C9 NSAIDs Hypoglycemics Angiotensin II Blockers (Sartan) Celecoxib Sulfamethoxazole Torasemide Warfarin. 2D6 β- Blockers Antiarrhythmics Antidepressants Antipsychotics Antiemetics Opiods . 2C19 PPI (Prazole)

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Pharmacology Summary notes

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  1. 4MedStudents.com Pharmacology Summary notes Unit 9 R.E.A

  2. 2C9 • NSAIDs • Hypoglycemics • Angiotensin II Blockers (Sartan) • Celecoxib • Sulfamethoxazole • Torasemide • Warfarin • 2D6 • β- Blockers • Antiarrhythmics • Antidepressants • Antipsychotics • Antiemetics • Opiods • 2C19 • PPI (Prazole) • Anti-epileptics • 1A2 • Riluzole • Tacrine • Theophylline • Clozapine Prof. Petroianu Cytochrom P450 3A4 • Substrates • Macrolide Antibiotics • BZD • Immune Modulators (cyclosporine) • Statin • Ca channel Blockers • Activators • Barbiturates • Carbamazepine • Glucocorticioids • Phenytoin • Rifampin • St.John’s worts • Inhibitors • Azole Antifungals • Cimetidime • Ciprofloxacin • Erythromycin • Grape fruit

  3. Prof. Petroianu N-Acetyle- Transferase (NAT) • Hydralazine* • Side effects: • Lupus like Syndrome • Neuropathy • Isoniazid* • Side effects: • - Neuropathy ( Vitamin B6) • Seizures ( GABA) • Lactic Acidosis • Lactic acid Pyruvate • Palagra: dermatitis, diarrhea, dementia, death) • Lupus like Syndrom • Procaine-Amide* • Side effects: • Lupus like Syndrome • Torsades de pointes • CNS:psychotic reactions • Sulfa Drugs* • Side effects: • Steven’s Johnson Syndrome • Epidermal necrolysis * Drugs Metabolized by N-Acetyle Transferase

  4. Prof. Petroianu UDP Glucuronyl-Transferase Irinotecan* Acetaminophen* = Paracetamol * Drugs metabolized by UDP Glucuronyl-Tansferease. If UDP Glucuronyl-Tansferease was genetically defected it will lead to hepatotoxicity.

  5. Prof. Petroianu G6PD* Sulfa Drugs** Anti-malarias drugs** primaquine Anti-Microbial drugs** chloramphenicol *G6PD protects the RBC from oxidative stress, deficiency of G6PD will cause distribution of RBC Anemia ** Drug s that causes Oxidative stress in G6PD deficiency

  6. Prof. Petroianu Thio-Purine-Methyl-Transferase 6-mercaptopurine* 6- Thioguanine* Azatthiopine* * Drugs metabolized by Thio-Purine-Methyl-Tansferase. TPMT deficient patients can develop hematological toxicity

  7. Prof. Petroianu Glutathione-S-Transferase* • Activators • Broccoli • Inhibitors • ethacrynic Acid • Sulfa drugs • Anti-malaria drugs (Qunine) *Is an enzyme that will help reduce toxicity

  8. Prof. Petroianu Dihydro-Pyrimidine-Dehydrogenase Capecitabine* 5-Fluorouracil* 5- deoxy Fluorouracil * Drugs metabolized by Dihyro-Pyrimidine-Dehydrogenase

  9. Cytotoxic Antibiotics • Doxorubicin ( Topoisomerase II) • Bleomycin Superoxide Break DNA • Metamycin • Dactinomycin ( Topoisomerase II and RNA Polymerase) Prof. Adem ChemotherapyCytotoxic Drugs • Anti-Metabolites- Methotrexate ( Dihydrofolate reductase) • Flurouracil • Cytarabine • Mercaptopurine • Plant alkaloid • Vincristine inhibit mitosis at metaphase • Etoposide ( Topoisomerase II) • Alkylating Agents • (Cause Cross link) • Cyclophosphamide • Lomustine • Cisplatin Hormones • Drugs inhibit sex hormone release • Formestain • aminoglutathmide • Breast tumors Glucocoticoids Leukaemia & lymphoma Oestrogen Prostate tumors Tamoxifen (anti-oeastrogen) Prostate tumors • GTRH analogues • Leuprolide • geserline • Prostate tumors & breast tumor Flutamide ( Anti-androgens) Prostate cancer

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