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Vitamin E decreases bone mass by stimulating osteoclast fusion

Vitamin E decreases bone mass by stimulating osteoclast fusion. Osteoscoop - Issue N°256 – October 2012. Normal bone mass. Ttpa -/-. High bone mass. Low vitamin E a - tocopherol serum concentration. Decreased bone resorption. Normal bone mass. Ttpa -/-. High bone mass. Low vitamin E

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Vitamin E decreases bone mass by stimulating osteoclast fusion

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  1. Vitamin E decreases bone mass by stimulating osteoclast fusion Osteoscoop - Issue N°256 – October 2012

  2. Normal bone mass Ttpa-/- High bone mass Low vitamin E a-tocopherol serum concentration Decreased bone resorption

  3. Normal bone mass Ttpa-/- High bone mass Low vitamin E a-tocopherol serum concentration Decreased bone resorption Maturation Fusion Unfused differentiated osteoclasts Fused osteoclasts

  4. Normal bone mass Ttpa-/- High bone mass Low vitamin E a-tocopherol serum concentration Decreased bone resorption Non-fusedosteoclasts Maturation Fusion Vit E Unfused differentiated osteoclasts Fused osteoclasts Tm7sf4 P P P Fused osteoclasts Mitf Mitf Mitf p38a p38a

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