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Presented by First Lastname, MD Name of Practice Group

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Presented by First Lastname, MD Name of Practice Group

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    2. THE SITUATION Over 6,000 people died last year from ruptured thoracic aortic aneurysms (TAA). 21,000 were diagnosed with this dangerous condition. Once a TAA ruptures, the survival rate is only 15%. Could your patient have an undiagnosed TAA?

    3. TAA ESSENTIALS Diameter of the thoracic aorta 1.5 times greater than normal (or larger)

    4. TAA ESSENTIALS 21,000 new cases per year in the U.S. Men: 60%, Women: 40% Elective repair: up to 10% mortality Emergent repair: up to 50% mortality

    5. WHO IS AT RISK Smoking Hypertension High cholesterol Obesity Atherosclerosis Chest trauma Genetics Marfans, Ehlers-Danlos Family history

    6. SYMPTOMS Neck, chest or back pain (25%) Shortness of breath Difficulty swallowing Hoarse cough Congestion of head, neck, upper extremities (related to SVC compression)

    7. DIAGNOSIS CT the definitive exam MRI Chest x-ray Aortogram TEE

    8. TREATMENT OPTIONS TAAs under 5.0 cm: medical therapy, monitor annual growth by CT TAAs over 5.0 cm in diameter: intervention/repair strongly considered Medical management (BP-lowering drugs) Open surgery Endovascular repair No proven lifestyle changes can decrease the size of TAAs. TEVAR animation video

    9. REPAIR OPTIONS Both endovascular and open surgeries are used to repair TAAs. Approximately 11,000 open surgeries are performed each year in the U.S. Approximately 8,000 endovascular repairs are performed in the U.S. annually.* *BIBA Medical Research estimated 1,960 thoracic stent grafts were implanted in the U.S. in Q2 2008.

    10. REPAIR OPTIONS Requires single small incision in the groin area. An endovascular graft is inserted through the femoral artery via a catheter and deployed inside the lumen, relining the aorta. Average ICU stay: 2-3 days Average recovery time: 1-2 weeks

    11. REPAIR OPTIONS Requires thoracotomy Aorta is cross-clamped above diseased aortic segment Affected segment is replaced with fabric surgical graft Average hospital stay: 2-3 weeks Average recovery time: 3 months

    12. THREE CLINICAL TRIALS 2005 TAG Pivotal Trial (N=139) 2008 TX2 Pivotal Trial (N=160) 2008 Talent Pivotal Trial (N=195)

    13. ENDOVASCULAR STENT GRAFT TRIALS

    14. WHAT YOU CAN DO? Remember those most at risk: Men over 60 Smokers Those with a family history of TAA Image and refer as appropriate those patients with a high index of suspicion for TAA.

    15. PHYSICIAN INFORMATION Name Address Phone E-mail

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