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CRCHD : Research and Training Opportunities

CRCHD : Research and Training Opportunities. Dr. Sanya A. Springfield, Director Center to Reduce Cancer Health Disparities NCI Division of Cancer Biology New Grantee Workshop March 15, 2013. NIH/NCI CRCHD Mission. *CHD: Cancer Health Disparities.

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CRCHD : Research and Training Opportunities

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  1. CRCHD:Research and Training Opportunities Dr. Sanya A. Springfield, Director Center to Reduce Cancer Health Disparities NCI Division of Cancer Biology New Grantee Workshop March 15, 2013

  2. NIH/NCI CRCHD Mission *CHD: Cancer Health Disparities

  3. Center to Reduce Cancer Health Disparities

  4. Basic Research – CRCHD/DCB Collaboration CRCHD R21/U01 • Understanding Biological Variations • Determining Mechanisms and Pathways • Creating Tailored Diagnostics/Therapies

  5. Exploratory/Developmental Grant for Basic Cancer Research in Cancer Health Disparities (R21) PAR-12-094 To support pilot and feasibility studies and innovative mechanistic studies that investigate biological/genetic bases of cancer health disparities • All Eligible • Preliminary data is not required • $275K Direct Cost Limit for 2 year project period • http://grants.nih.gov/grants/guide/pa-files/PAR-12-094.html

  6. Basic Cancer Research in Cancer Health Disparities (U01) PAR-12-095 To conduct basic, mechanistic research into the biological/genetic causes of cancer health disparities. • All Eligible • Preliminary Data Required • $250K Direct Cost Limit per year and not to exceed 5 years • http://grants.nih.gov/grants/guide/pa-files/PAR-12-095.html

  7. R21/U01 Basic Research in Cancer Health Disparities (PAR-12-094/095) * 1 Lymphoma, 1 Multiple Cancers, 1 Wilms Tumor • Topics of U01 grants funded in FY 2012 • Inflammatory Differentiation of Colorectal Cancer Among African Americans • Metabolomic profiling and biologic basis of racial disparity in prostate cancer • Etiology of cervical cancer health disparity in American Indian women • Systematic Genetic Characterization of African American Prostate Cancer • Basic Cancer Research in Cancer Health Disparities • A Genetic Model for Early-Onset Breast and Colon Cancer in African Americans • Topics of R21 grants funded in FY 2012 • Biological Variants Underlying Racial Differences in Lymphoma • Xenograft Model to Study Impact of CRLF2-Ligand in Hispanic Childhood B-ALL • Impact of Mitochondrial Genome Variation on extreme Prostate Cancer Disparities

  8. TCGA Opportunity Explore the ideas and potential areas of collaboration between TCGA and CRCHD partnerships to establish future funding opportunities and team science approach in biospecimen translational research efforts.  • Breast and prostate cancer focus plus select other cancers • Tumor tissue plus blood from same patient • Minimum 10 cases to establish a contract (for one year) • Compatible with TCGA guidelines: • Primary tumor only (except for melanoma) • Snap frozen, 50-60 mg • No more than 20% necrosis; ; ≥ 60% tumor cells • Normal tissue:  Blood (buffy coat/white cells); adjacent normal tissue or buccal cells; or ≥ 20µg high-quality DNA • All “Tier One” clinical Data Elements (15 or more) • Questions? Dr. Anil Wali at walia@mail.nih.gov http://cancergenome.nih.gov/

  9. Diversity Training Training CURE Promoting Workforce Diversity in Cancer Research (R21)

  10. Continuing Umbrella of Research Experiences (CURE) Expand and extend the period of training Increase the size of the talent pool Emphasize scientific areas of greatest need TRAINEES Pre -doctoral Early Stage Investigator High School Undergraduate Postdoctoral

  11. Continuing Umbrella Research Experiences HS Undergrad. Predoctoral Postdoctoral Early Stage Investi. Diversity Supplements R 0 1 Re-Entry Supplements NRSA Fellowships: F31 R21 NRSA Training Grants:T32S P30 Supplements for HS and UG students R25TS: Cancer Prevention and Control Clinical Oncology Training Grants: K12S Career Awards: K01 K08 K23 Transition Career: K22

  12. Research Supplements to Promote Diversity and Re-Entry Research Supplements to Promote Diversity in Health-Related Research (Administrative Supplement) http://grants.nih.gov/grants/guide/pa-files/PA-12-149.html • Improve the diversity of the research workforce • Students, post doctorates, and eligible investigators • Research Supplements to Promote Re-Entry into Biomedical and Behavioral Research Careers (Administrative Supplement) • http://grants.nih.gov/grants/guide/pa-files/PA-12-150.html • Individuals with high-potential to re-enter an active research career after an interruption for family responsibilities or other qualifying circumstances • Support for full-time or part-time research, salary and supplies within the missions of all the program areas of NIH.

  13. CURE – NRSA Fellowships (F31) • Ruth L. Kirschstein National Research Service Awards for Individual Pre-doctoral Fellowships • Pre-doctoral (up to 5 years) support for candidates in • biomedical, behavioral, or clinical sciences • Fellowship Requirements – Experienced mentor, enrollment in a • graduate school • Allowable Costs – Annual stipend for Fellow’s living expenses, • tuition & fees, and health insurance • Submission dates – 4/13, 8/13, 12/13 (Electronic Submission) • http://grants.nih.gov/grants/guide/pa-files/PA-10-109.html

  14. Supplements to the CURE Program(R25TS, K12S, T32S) Submission Periods: Oct 1-Dec 1; Mar 1-May 1 Electronic/Paper Submission NCI Cancer Education and Career Development Program (R25TS) http://grants.nih.gov/grants/guide/pa-files/PAR-12-051.html Up to 5 years support: Pre Doc; Up to 3 years support: Post Doc Clinical Oncology Research Development (K12S) http://crchd.cancer.gov/attachments/guidelines/Guidelines_for_K12_Supplement.pdf Up to 3 years support NRSA Institutional Training Grant (T32S) http://grants.nih.gov/grants/guide/pa-files/PAR-12-051.html Up to 5 years support: Pre Doc; Up to 3 years support: Post Doc Accepted Throughout the Year

  15. Mentored Career Development Award (K) NCI Mentored Research Scientist Development Award to Promote Diversity (K01) PAR-12-050 BASIC/POPULATION SCIENCE • Individuals with Research or Health Professional Doctoral Degree • 100K Salary/30K R&D ; • 3 - 5 years support NCI Mentored Clinical Scientist Research Career Development Award to Promote Diversity (K08) PAR-12-05 TRANSLATION • Individuals with Health Professional Doctoral Degree • 100K Salary/30K R&D; • 3 - 5 years support NCI Mentored Patient-Oriented Research Career Development Award to Promote Diversity (K23) PAR-12-052 CLINICAL • Individuals with Health Professional Doctoral Degree • 100K Salary/30K R&D; • 3 - 5 years support Submission Dates: 2/12, 6/12, 10/12

  16. Non-Mentored Career Development Award (K22) • Transition Career Development Award to • Promote Diversity (K22) • PAR-12-096 • BASIC, TRANSLATION, POPULATION & CLINICAL • Individuals with research or health professional doctorate degree • 100K Salary/50K R&D; 3 years support • Submission Dates: 2/12, 6/12, 10/12

  17. Exploratory Grant Award to Promote Workforce Diversity in Basic Cancer Research (R21) PAR-12-096 To improve the diversity of the research workforce by supporting and recruiting eligible investigators from groups that have been shown to be underrepresented. • Eligibility: Investigators from Diverse Backgrounds • Preliminary Data is encouraged • $275K Direct Cost limit for 2 year project period • http://grants.nih.gov/grants/guide/pa-files/PAR-12-096.html

  18. R21 Exploratory Grant Award to Promote Workforce Diversity in Basic Cancer Research (R21) PAR-12-096 • FY12 Current R21 Research • Plasticity of Mammary Adipose and Breast Cancer Development • Taming of T-regulatory Cells Following Tumor Irradiation • Human Papilloma Virus Infection in Patients with Colorectal Cancer • Tumorigenic Potential of Tumor Adjacent Histologically Normal Breast Tissue • Notch-1 in T Cells: A Central Mediator of Tumor Induced Energy • Discovery and Targeting of Apoptosis Resistance Mechanisms in High-Risk T-ALL • Preventing Prostate Cancer Progression by ASC Delivery of PEDF and IFNb • Cancer Cell Overexpression of Death Receptor Modulator • Targeting Akt with Substrate Mimetic Antagonists

  19. Basic Cancer Research Grants (R21 and U01) • Dr. Rina Das dasr2@mail.nih.gov • Community Networks Program Centers • Dr. Rina Das dasr2@mail.nih.gov • Dr. Liz Perrucioperruccioem@mail.nih.gov • Dr. Precilla Belin belinpl@mail.nih.gov • Diversity Supplements and U54 • Dr. Peter Ogunbiyi ogunbiyp@mail.nih.gov • NRSA (F31 and T32S) • Dr. Alessandra Bini binia@mail.nih.gov • Supplements to the CURE (P30S, R25TS, K12S) • Dr. Alison Lin alision.Lin@mail.nih.gov • Career Development Awards (K) • Dr. John Ojeifo (K01, K08, K23) Ojeifojo@mail.nih.gov • Dr. Anil Wali (K22) walia@mail.nih.gov • Exploratory Grant (Diversity R21) • Dr. Anil Wali walia@mail.nih.gov • PACHE Program (P20, U54) • Dr. Carmen Moten cmoten@mail.nih.gov • CRCHD General Contact Number: 301-496-8589

  20. CRCHD Web Site http://crchd.cancer.gov

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