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The Liver is Super Super Awesome

The Liver is Super Super Awesome

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The Liver is Super Super Awesome

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  1. The Liver is Super Super Awesome Olga Filippova, MunirNahri, Akash Patel BMES 471

  2. Anatomy of the Liver1 • Most metabolically complex organ • 2 main, 2 smaller lobe • Eight segments • Functional unit – lobule • Dual blood supply • Portal vein (75%) • Hepatic artery (25%) • Hepatocyte plates • Endothelial, Kupffer’s, Fat-storing, Pit http://education.vetmed.vt.edu/curriculum/vm8054/labs/Lab20/LAB20.HTM Lobule, the functional unit of the liver, and its circulatory system

  3. Functions of the Liver1 • Metabolism • carbohydrate, protein, fat • Glucose regulation - glucogenesis, glucogenolysis • Amino acid catabolism • Drug neutralization • Bile synthesis • digestion and absorption of fat • Cholesterol catabolism • Stored in gallbladder • Released by CCK from SI

  4. Current State of Liver TE • Pgusighisghsdg

  5. Current State of Liver TE • Pgusighisghsdg

  6. Room for Improvement • Pgusighisghsdg

  7. Room for Improvement • Pgusighisghsdg

  8. Future of Liver TE2 • Goals for development • Artificial liver • Used to study disease progression models • Bio-artificial liver • Hope for Acute Liver Failure patients • Use of viable cell sources • Primary porcine hepatocytes – most common3 • Relatively low cost, increase availability, safe • Progenitor stem cells → functional hepatocytes4 • Control, differentiation and proliferation • Promote phenotypic stability and tissue morphogenesis

  9. Future of Liver TE2 • Extracorporeal bioartificial liver Devices • Bidirectional mass transport • Stable microenviornment • Hepatocytes require specific environment to maintain function4 • Scale Up • Examples: • Hollow fiber devices, Flat plate systems, perfusion bed/ scaffolds, suspension and encapsulation4

  10. References • Hilsden, R.J., Shaffer, E.A. Chapter 14: The Liver, 1. Liver Structure and Function. First Principles of Gastroenterology: the basis of Disease and an Approach to Management. Canadian Association Pf Gastroenterology. 1994. • Gerlach, J.C., Zeilinger, K., Patzer, J.F. II. Bioartificial Liver Systems: Why, What, Whither? Regenerative Medicine. 3, 575, 2008. • Behnia, K., Bhatia, S., Jastromb, N., Balis, U., Sullivan, S., Yarmush, M., Toner, M. Xenobiotic Metabolism by Cultured Primary Porcine Hepatocytes. Tissue Engineering. 6, 467, 2000. • Allen, J.W., Bhatia S. N. Engineering Liver Therapies for the Future. Tissue Engineering. 8, 725, 2002.

  11. Questions? Olga Filippova, MunirNahri, Akash Patel BMES 471