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Questionnaires and Interviews

Questionnaires and Interviews. Steven R. Cummings, MD Director, S.F. Coordinating Center. Where we left my story…. Resveratrol increases speed, endurance & strength & lifespan My hypothesis: Those who consume resveratrol have longer healthy life

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Questionnaires and Interviews

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  1. Questionnaires and Interviews Steven R. Cummings, MD Director, S.F. Coordinating Center

  2. Where we left my story… • Resveratrol increases speed, endurance & strength & lifespan • My hypothesis: Those who consume resveratrol have longer healthy life • A randomized trial for mortality was too big and NIA didn’t fund my small trial of resveratrol and gait speed • So…

  3. An opportunity to piggy back • A SFCC study about aging is planning a new visit • Men ≥ age 75 years old • I could add questions about intake of resveratrol • I could test subsequent mortality or cross-sectional associations with health • …cheaply • But additions must be short

  4. Measurements I need to test my hypothesis • “Resveratrol intake” • “Healthy” • “Lower mortality”

  5. Measurements I need to test my hypothesis • “Resveratrol intake” • “Healthy” • “Lower mortality” • But insufficient number of men taking resveratrol and too few deaths to test whether resveratrol is associated with mortality

  6. Measurements I need to test my revised hypothesis • “Resveratrol intake” • “Health”

  7. I need questions to assess • “Resveratrol intake” • “Health”

  8. 1st step • Are there standard questionnaires? • Must I make my own?

  9. Where to find questionnaires • Experts and articles in the area of research • Search the web • e.g. QualityMetrics: www.qualitymetric.com • General health status (SF36) • A few disease-specific measurements • Must get a license • SF Coordinating Center

  10. Resveratrol intake comes mainly from red wine and supplements • I need to quantify the average amount of resveratrol the participant takes • Add questions about red wine intake • Add questions about use of resveratrol supplements

  11. The Coordinating Center has a standard questionnaire on alcohol use • Basic questions • Have you drunk at least 12 ‘drinks’ of alcohol in past 12 months? If yes • Average drinks per week. • Easily modified to substitute ‘red wine’ for ‘alcohol’

  12. The Coordinating Center also has a standard questionnaire on medication use • Do you currently take ____? __ No (skip to X) __ Yes • How often? • __ daily __ weekly __ less often • What dose? ___

  13. I must adapt the questionnaire to measure resveratrol intake • Do you currently take ____? __ No (skip to X) __ Yes • How often? • __ daily __ weekly __ less often • What dose? ___

  14. Quantifying resveratrol intake from supplements • Do you currently take tablets or capsules containing resveratrol? • Yes No (skip to X) • How often? • __ daily __ weekly __ less often • What dose? _____ • X…

  15. Quantifying resveratrol intake from supplements • Do you currently take tablets or capsules containing resveratrol? • Yes No (skip to X) • How often? • __ daily __ weekly __ less often • What dose? _____ What’s wrong with this question?

  16. Quantifying resveratrol intake from supplements “Or” can be confusing • Do you currently take tablets or capsules containing resveratrol? • Yes No (skip to X) • How often? • __ daily __ weekly __ less often • What dose? _____ It is also sold as a liquid Some are not called ‘resveratrol’ May not know; not on label These problems might be discovered by pretesting with people who take resveratrol

  17. Clarified the question…but • Do you currently take supplements containing resveratrol? • Yes No (skip to X) • How often? • __ daily __ weekly __ less often • What dose? _____ Some are not called ‘resveratrol’ May not know; not on label

  18. Clarified the question…but • Do you currently take supplements containing resveratrol? • Yes No (skip to X) • How often? • __ daily __ weekly __ less often • What dose? _____ • What brand? _____ Some are not called ‘resveratrol’ May not know; not on label Only few brands are absorbed

  19. Assessing intake by interview • Please bring all of the medications or supplements that you have taken in the past month • Frequency of use • __ daily __ weekly __ less often • Dose __ __ __ mg • Brand _________ Open ended Must be coded with a dictionary

  20. Some assessments are difficult and inherently imperfect • Intakes • Activity • Sleep Prefer • Direct measurements

  21. Some assessments are difficult and inherently imperfect • Intakes Blood or urine levels • Activity Monitors • Sleep Actigraphy; home devices Prefer • Direct measurements

  22. “Health” • MrOS uses the SF-12 to assess health status • It is extensively validated • For example, large differences between patients with and without chronic disease • Changes in response to interventions, such as exercise or medical treatments

  23. ‘Standard’ or ‘validated’ instruments • Usually the best choice • Probably free(er) of bugs • Looks better in papers and grants • However, • May not measure what you want • May not apply to your population • May be longer than you need

  24. Questions in the SF-12(for patients > 70-95)

  25. Questions in the SF-12(for patients > 70-95) Some men >75 might not do these This might be discovered by pretesting men >75

  26. Questions in the SF-12

  27. Questions in the SF-12 Does resveratrol improve mood?

  28. Questions in the SF-12

  29. Questions in the SF-12 There is no reason to believe that resveratrol would relieve pain

  30. The ‘validated’ SF-12 • A good choice because • Extensively tested, few/no bugs • Would look better in papers and grants • However, • Does not measure ‘health’ related to speed, strength, endurance • Many questions about mood and pain • May not apply to men > age 75 years

  31. What do I want to measure? • Walking speed • Already to be measured in MrOs • General health question • Physical quality of life • Just the ‘physical’ components of SF-12

  32. Pretest, pretest, pretest • Start with a few friends or colleagues • Try it on 2 or 3 like subjects in your study • Men over age 75; extremes (age, education…) • Discuss the answers with the volunteers • Revise and retest • Test the ‘final’ in more and diverse subjects • Potential goals: clarity, time, frequency of answers • Bigger efforts: test reliability and validity

  33. Administering questions • Questionnaires are more efficient than interviews • If needed, follow-up review of questions • Sometimes, interviews are the only way • Make sure they are asked verbatim • Use electronic methods as much as possible • Online tools (mix of free & pay service) • www.surveymonkey.com • www.zoomerang.com • 11 reviewed at www.techsoup.org/learningcenter/software (search “online survey tools”)

  34. Summary • Carefully define what you want to measure • Search for ‘standard’ instruments • Do they measure what you want? • If you make your own: avoid pitfalls • Clarity; avoid “and,” “or” • Pretest, pretest, pretest…

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