SCIENCE IS THE ENGINE DRIVING NSE’s INNOVATION • Over 100 Full-Time Scientists - Many Disciplines Nutrition, Medicine Pharmacology, Biochemistry, Dietetics, Toxicology, Immunology, Physics, Biomedical Engineering • Dr. Joseph Chang - Chief Scientific Officer Photodynamic Cancer Therapy Drug (Brain Tumors) Etodolic (Arthritis Drug) Rapamune (Anti-Rejection Drug) • Research Partners - Purdue University, Life Gen Technologies, Stanford University, Harvard University • Anti-Aging Scientific Advisory Board - 20 Scientists • 3 Global Research Centers Power NSE’s Research and Development Engine
Beijing Clinical Center Provo, Utah Headquarters & Pharmanex Research Institute Shanghai R&D Center Huzhou Mfr. Plant Over 100 Scientists
NSE IS THE ONLY SCIENCE-BASED COMPANY WITH 2 ANTI-AGING PRODUCT BRANDS ageLOC Skin Care = ageLOC OUTSIDE ageLOC Nutritionals = ageLOC INSIDE
PHARMANEX SCIENCE + NU SKIN GUARANTEE: QUALITY INNOVATION SAFETY SUBSTANTIATED CLAIMS
25 Successful Years Publicly Traded on NYSE (NUS) Dunn & Bradstreet 5A1 Rating Operating in 50 Countries $1.3 Billion in Annual Sales 2009 2010 Projected Annual Sales Over $1.6 Billion = 23% Increase! Over $770 Million in Assets Over $180 Million in Cash Over $350 Million Spent on R&D Recognized & Featured in Numerous Media, Including Forbes Magazine & Investors Business Daily NSE – THE COMPANY BEHIND ageLOC
NU SKIN—YOUR TRUSTED PARTNER +19% Top 5 Mid-Cap Company
WHAT IS ? • A BREAKTHROUGH GENETIC APPROACH TO ANTI-AGING • A PLATFORM OF INNOVATIVE ANTI-AGING SOLUTIONS THAT TARGET AGE-RELATED GENES = THE ULTIMATE SOURCES OF AGING
THE GENE REVOLUTION 1953: James Watson and Francis Crick identify the structure of the DNA molecule 2003: The Human Genome is sequenced & the map is completed 2010: An entire new branch of science emerges 9
Old Paradigm: There is nothing you can do to influence your inherited genes and aging is inevitable. ageLOC Paradigm: Genes respond to the environment. Gene action & expression can be influenced and be restored to a more youthful state through targeted ingredient introduction.
GENESIS OF AGELOC Identification of age-related genes by pioneers of aging research Exclusive collaboration with LifeGen to develop gene-based anti-aging products ageLOC creates a sustainable competitive advantage with exclusive access to over 30 years of research into the genetic basis of aging.
SCIENCE SIMPLIFIED • IDENTIFY groups or clusters of genes which impact aging and understand their youthful expression patterns (Youth Gene Clusters or YGC’s); • ISOLATE - Investigate the aging effect of different ingredients on specific YGC’s in human tissues; • RESET - Develop formulae that reset these YGC’s back to their youthful state.
ageLOC BALANCES YGC ACTIVITY Genes that ACCELERATE aging Genes that promote YOUTH
Is it Safe to Influence Genes? X-MEN ageLOC is NOT: gene therapy genetic engineering gene splicing ageLOC IS: Nu Skin’s novel approach to developing products designed to support youthful gene expression.
ageLOC SCIENCE VALIDATED Genetics of Aging Symposium University of Tokyo
A MASS MARKET PRODUCT EVERYONE WANTS AT A PRICE EVERYONE CAN AFFORD! ageLOC science applied to internal body tissues – heart, brain & muscle tissues Influences genetic expression through targeted nutritional supplementation Clinically proven to increase PHYSICAL ENERGY, MENTAL ACUITY & SEXUAL DESIRE Only $50 for a month = $1.66/day!!!
IS NOT - A stimulant, drug, or chemicals IS - A proprietary BLEND of mushroom, ginseng, and pomegranate (a fruit, a root & a fungus) that have been thoroughly studied and proven safe, combined in clinical doses to influence our genetic expression IS - The result of 30+ years of research by hundreds of doctors & scientists, multiple patents, and hundreds of millions of dollars in R&D
MITOCHONDRIA: A KEY SOURCE OF YOUTHFUL VITALITY Mitochondria are the cellular power plants that convert energy from food (Kcals) into a form of energy our cells can use—ATP ATP fuels all biological functions With age, mitochondria number and efficiency declines dramatically Mitochondria dysfunction leads to age-related vitality loss
MITOCHONDRIA HIGHLY CONCENTRATED IN: Brain Heart Muscle
LATEST ageLOC DISCOVERY: ageLOC SCIENCE DISCOVERS THE GENETIC MECHANISM TO OPTIMIZE MITOCHONDRIAL POWER GENERATION Identified and influenced52 genes tied to mitochondrial function
RESTORE YOUTHFUL VITALITY ageLOC Vitality targets the sources of age-related vitality loss by promoting youthful expression of mtYGC.
BOTTOM LINE RESULTS Increased and sustained baseline ENERGY levels with NO stimulant effect Increased mental clarity, focus, ability to concentrate & productivity Increased libido More restful sleep and refreshed mornings Increased endurance & strength Better food choices & less appetite Regulated blood sugar Fewer aches and pains
A Global Consumer Need NO COMPARISON
$1.66 per day Demographic agnostic Increases energy and mental clarity Results in 7-12 days NO stimulants Price friendly - $50 for 180 capsules Available NOW in 6-packs!!! Will be available individually at the launch in January 2011
Anti-Aging Innovation Reducing the Size of Technology Download Media iTunes Store Proprietary Device with Consumable Gels & Complementary Products
ageLOCGalvanic Spa System II Instant Results – Unique, Emotional, Affordable! • Smoothes Lines and Wrinkles • Lifts and Increases Skin Firmness • Micro Cleanses Skin to Dermal Layer • Improves Skin Texture and Pore Size • Treatment Takes Only 5 Minutes 2-3/wk! Hand-held Patented Technology
VALUE Galvanic ageLOC Spa Package = $290 • Galvanic Spa Device – Can be used with ANY daily skin care regimen • 4 Interchangeable Heads • 8 Sets of Facial Treatment Gels (1 month) • 1 NaPCA Moisture Mist (1 month) • Cost per Treatment (after 1st 8 treatments)= $7.50!!!
The Most Advanced Product in Nu Skin History! FUTURE SERUM • Maximum concentration of ageLOC ingredients • ageLOC & other anti-aging ingredients clinically proven to significantlyimprove skin in 8 ways
Four YGCs Identified That Are Responsible for 8 Signs of Skin Aging 8 Signs of Aging Fine Lines & Wrinkles Youth Gene Clusters Youthful SkinStructure Discoloration Skin Tone Hydration Texture, Smoothness Radiance Pore Size
VALUE FUTURE SERUM • Can be used with ANY daily skin care regimen • Twice daily application • $157 for 30 day supply • Compare to leading anti-aging serums: • Chanel – Subimage = $400.00 • Estee Lauder – Re-Nutriv = $140.00 • Lancome – Secret De Vie = $265.00 • La Prairie – Radiance Collection =$570.00