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Today. Vitamins, minerals, & deficiency diseases Synergies between nutrition & disease Especially vulnerable populations 4 faces of hunger. Contemporary acute deficiency diseases: Iron. Iron deficiency : Most common single nutrient deficiency in the world

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today
Today
  • Vitamins, minerals, & deficiency diseases
  • Synergies between nutrition & disease
  • Especially vulnerable populations
  • 4 faces of hunger
contemporary acute deficiency diseases iron
Contemporary acute deficiency diseases: Iron
  • Iron deficiency:
    • Most common single nutrient deficiency in the world
      • > 1/3 of pop in many developing countries
    • Reduces cognitive performance, energy and work ability, and resistance to infection (especially to diarrheal and respiratory diseases) even in mild cases
    • Severe forms = anemia
contemporary acute deficiency diseases iodine
Contemporary acute deficiency diseases: Iodine
  • Iodine deficiency:
    • Iodine is lacking in soils from some mountain areas and in domr highly leached soils
      • e,.g., Andes, Himalayas, C Africa, SE Asia...
    • Major consequences:
      • Swelling of thyroid (goiter)
      • Important mental deficiencies (cretinism) in kids if deficient in pregnant women
contemporary acute deficiency diseases vitamin a
Contemporary acute deficiency diseases: Vitamin A
  • Vitamin A deficiency:
    • Major consequences
      • To vision can lead to blindness
      • Also decreased immune function
      • Kids with severe protein-calorie malnutrition often have impaired sight as a result of this
synergy nutrition and disease
Synergy: nutrition and disease
  • Poor nutrition (protein-calorie or other nutrient shortages) => reduced ability to fend off new infections or makes existing ones more severe
  • Diseases interfere with nutrient absorption and/or actively deplete nutrients from our bodies
how poor nutrition disease
How poor nutrition => disease
  • Reduction in the body's innate immunities (that react to general patterns of proteins in pathogens)
    • Less effective phagocytosis (process by which microorganisms are engulfed and encapsulated)
    • Weakened epithelial barriers (protective coverings on body surfaces inside and out)
    • Lowered lysozyme production (a bodily protein that functions as an antibacterial)
how poor nutrition disease ii
How poor nutrition => disease II
  • Reduction in ability to generate acquired immunities - the specific immunities one acquires to a particular disease pathogen
    • Reduced production of humoral antibodies
    • Impaired cell-mediated immunity
how disease poor nutrition
How disease => poor nutrition
  • Most infections interfere with the body's ability to absorb nutrition and/or actively deplete nutrients
    • Reduced appetite
    • Poorer quality of diet ingested
    • Diseases deplete bodily tissue
    • Fevers => increased metabolic rate thus, the body needs more kcal but they may not be there
special case of gi tract diseases
Special case of GI tract diseases
  • 1.8 billion cases/yr of infant/weanling GI diseases
  • Predominantly diarrheas, but also intestinal parasites, cholera, & various types of dysentery
    • Impede absorption of nutrients (diarrheas just don't let food sit in gut long enough)
special case of gi tract diseases ii
Special case of GI tract diseases II
  • Many if not most deaths (perhaps 1 million/ yr in the world) can be averted with adequate treatment (called Oral Rehydration Therapy)
    • According to The Lancet (1978), ORT is "potentially the most important medical discovery of the 20th century"
    • Clean water with 60 cent packets of salts/sugars to recover health
    • Full recovery => increased nutrition above basic levels – often hard to get
slide11
Oral Rehydration Therapy

(packet for addition to water)

Oral Rehydration Therapy

(home made)

especially vulnerable populations i
Especially vulnerable populations I
  • Increased likelihood of malnutrition and more serious consequences
  • Women in general due to cultural traditions that privilege food to males
  • Pregnant women
    • Poor nutrition => low birth weight babies
    • Developmental problems for baby physically and mentally
    • Reduced resistance to diseases
    • Less able to breast feed (=> less resistance for the baby as well)
especially vulnerable populations ii
Especially vulnerable populations II
  • Lactating women
    • Poor nutrition seldom greatly interferes with ability to produce milk
    • But, poor nutrition does deplete the mother's body of necessary nutrients
    • If nutrition is not better between end of lactation and next pregnancy => spiral down to chronic anemia etc.
  • Elderly
    • Ability to fend off infections is reduced with great age and malnutrition hurts that as well
especially vulnerable populations iii
Especially vulnerable populations III
  • Children
    • Malnutrition in infants and children very problematic if timing coincides with critical growth processes
      • Up to age 5 risk is greatest
    • Especially at weaning age (approx 2 yrs)
    • Due to impure water used to make weaning foods (not sufficiently boiled due to lack of fuel) and general low hygiene =>
      • Kids die from diarrheal diseases and dehydration and malnutrition
    • Weaning foods are typically not nutrient-rich enough (e.g., maize gruels)
four faces of hunger i
Four Faces of Hunger I
  • I. Starvation/Famine
    • Widespread to complete lack of protein/calorie nutrition
    • A small percentage of global hunger – perhaps 1% at risk annually
    • Leads to increased mortality (usually to infectious diseases not starvation per se)
    • Great social disruption => increased problems with diseases and access to food
    • In any famine not all starve – the well off can buy food -- thus NOT usually only a simple shortage
four faces of hunger ii
Four Faces of Hunger II
  • II. Malnutrition/Undernutrition
    • Seasonal or periodic P/C under-nutrition
    • Most serious effects on kids and special needs adults (pregnant and lactating women, the elderly)
    • measures of malnutrition in children
      • Stunting - stature too short for age/sex (adjusted for local norms) => chronic
      • Wasting – weight too light for age/sex (adjusted for local norms) => acute
four faces of hunger iii
Four Faces of Hunger III
  • III. Micro-nutrient deficiencies
    • Vitamin and mineral shortages
    • Sometimes called “hidden hunger”
  • IV. Nutrition-depleting illnesses
    • Secondary malnutrition
    • Most common nutrient depleting diseases are infant/weanling diarrheas – 5 million deaths annually world wide
global hunger
Global Hunger
  • Global situation late 1990s
  • Data drawn from FAO’s SOFA report 2007
  • http://www.fao.org/docrep/010/a1200e/a1200e00.htm
  • The International Food Policy Research Institute:
  • http://www.ifpri.org/media/20071012GHI.asp
  • The concept of “food security”
global trajectories of hunger i
Global Trajectories of Hunger I
  • Proportions undernourished (or food insecure)
    • Late 1970s ~ 28%
    • Late 1990s ~17%
    • Thus, some real progress
    • Less progress in absolute numbers
  • Micro-nutrient deficiencies
    • Iron: 40% of global south
    • Iodine: 12% of global south
    • Vitamin A: 14% of kids in global south
global trajectories of hunger ii
Global Trajectories of Hunger II
  • Absolute numbers undernourished (or food insecure)
    • 1970s ~ 900m; 2000 ~ > 800 m
    • => decrease of ~ 100m in absolute numbers (but smaller %)
  • Children 1993 ~ 200 m; now ~ 175 m
  • World food summit target (MDG) in 2015 => 400m
    • Current trajectory => 475-500m by 2015
    • Progress in some places, regression in others
regional differences malnourished or food insecure
Regional differences malnourished or food insecure
  • Global South
    • Sub-Saharan Africa
    • E. Asia, SE Asia, & Pacific
    • South Asia
    • Latin America & Caribbean
    • Near East & N. Africa
  • Developed Economies (mostly N America)
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