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  1. SDC 1. ß-lactam-resistant Streptococcus pneumoniae clustered by MLST SLV, labeled by serotype, color-coded by complex. 19F 14 1 1 1 1 1 1 1 1 1 6 6 6 6 6 6 6 6 6 Clonal complex: Green Spain 9V-3 Yellow Columbia 23F-26 Blue England 14-9 Orange Taiwan 19F-14 Purple ring SLV ST-753 Peach ring SLV ST-751 Turquoise ring SLV ST-353 Gray Singleton 14 14 14 14 14 14 11F 5 5 5 5 5 5 5 5 5 1 1 1 1 1 1 1 1 1 14 14 14 14 14 14 14 14 14 6B 3 3 3 3 3 3 3 3 3 4 4 4 4 4 4 4 4 4 6B 4 4 4 4 4 4 4 4 4 5 5 5 5 5 5 5 5 5 6B 23F 23F 14, 23F 1 1 1 1 1 1 1 1 1 23F 1 1 1 1 1 1 1 1 1 2 2 2 2 2 2 2 2 2 23B 14 14 5 5 5 5 5 5 5 5 5 3 3 3 3 3 3 3 3 3 2 2 2 2 2 2 2 2 2 23F 23B

  2. SDC 2. ß-lactam-susceptible Streptococcus pneumoniae clustered by MLST SLV, labeled by serotype, color-coded by complex. Clonal complex: Green Spain 9V-3 Light blue SLV ST-393 Yellow Columbia 23F-26 Light green SLV ST-289 Blue England 14-9 Light yellow SLV ST-439 Red Taiwan 23F-15 Light purple SLV ST-320 Purple Tennessee 14-18 Light orange SLV ST-239 Turquoise Greece 21-30 Fuschia pink Portugal 19F-21 Blue font SLV ST-15 Pink Portugal 6A-41 Red font SLV ST-757 Brown Netherlands 7F-39 Green font SLV ST-770 Brick red Netherlands 8-33 Orange font SLV ST-162 Gray Singleton No color No complex 16F 4 4 4 4 4 4 4 4 4 9V 1 1 1 1 1 1 1 1 1 9V 4 4 4 4 4 4 4 4 4 6B 2 6B 6A 6A 6A 4 1 1 1 1 1 1 1 1 1 23F 6A 6A 4 4 4 4 4 4 4 4 4 4 6B 19F 2 5 5 5 5 5 5 5 5 5 35F 1 1 1 1 1 1 1 1 1 NT 38 38 6B 5 5 5 5 5 5 5 5 5 4 14 14 19F 15B NT 4 4 4 4 4 4 4 4 4 1 1 1 1 1 1 1 1 1 4 4 4 4 4 4 4 4 4 5 5 5 5 5 5 5 5 5 4 19F 19F 20 1 1 1 1 1 1 1 1 1 6A 4 4 4 4 4 4 4 4 4 14 5 5 5 5 5 5 5 5 5 3 3 3 3 3 3 3 3 3 14 14 14 10A 13 1 1 1 1 1 1 1 1 1 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 23B NT 3 5 14 9N NT 9N 5 5 5 5 5 5 5 5 5 11A 1 1 1 1 1 1 1 1 1 4 4 4 4 4 4 4 4 4 20 23F 2 4 4 4 4 4 4 4 4 4 4 2 2 2 2 2 2 2 2 2 4 4 4 4 4 4 4 4 4 23A 10A 10A 8 3 3 3 3 3 3 3 3 3 23F 4 4 4 1 1 1 1 1 1 4 4 4 4 4 4 1 1 1 5 2 2 2 2 2 2 2 2 2 4 1 1 1 1 1 1 1 1 1 2 13 6A 4 4 4 4 4 4 4 4 4 4 35F 4 6B 4 4 4 4 4 4 4 4 4 5 5 5 5 5 5 5 5 5 8 7C 34 4 4 4 4 4 4 4 4 4 5 5 5 5 5 5 5 5 5 14 40 6A 6A 3 3 3 3 3 3 3 3 3 23F 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 6A NT 18C NT NT 17F 17F 5 5 5 4 4 4 4 4 4 5 5 5 5 5 5 4 4 4 9N 10A 5 5 5 5 5 5 5 5 5 10A 2 5 5 21 1 1 1 1 1 1 1 1 1 5 21 28A

  3. SDC 3. ß-lactam-susceptible Streptococcus pneumoniae clustered by MLST SLV, labeled by ST, color-coded by complex. Clonal complex: Green Spain 9V-3 Light blue SLV ST-393 Yellow Columbia 23F-26 Light green SLV ST-289 Blue England 14-9 Light yellow SLV ST-439 Red Taiwan 23F-15 Light purple SLV ST-320 Purple Tennessee 14-18 Light orange SLV ST-239 Turquoise Greece 21-30 Fuschia pink Portugal 19F-21 Blue font SLV ST-15 Pink Portugal 6A-41 Red font SLV ST-757 Brown Netherlands 7F-39 Green font SLV ST-770 Brick red Netherlands 8-33 Orange font SLV ST-162 Gray Singleton No color No complex 765 4 4 4 4 4 4 4 4 4 752 1 1 1 1 1 1 1 1 1 162 4 4 4 4 4 4 4 4 4 769 2 759 759 759 756 4 1 1 1 1 1 1 1 1 1 242 757 744 4 4 4 4 4 4 4 4 4 4 751 51 2 5 5 5 5 5 5 5 5 5 745 1 1 1 1 1 1 1 1 1 755 755 755 750 5 5 5 5 5 5 5 5 5 4 722 722 177 15B 191 4 4 4 4 4 4 4 4 4 1 1 1 1 1 1 1 1 1 4 4 4 4 4 4 4 4 4 5 5 5 5 5 5 5 5 5 4 763 749 1 1 1 1 1 1 1 1 1 762 327 4 4 4 4 4 4 4 4 4 738 5 5 5 5 5 5 5 5 5 3 3 3 3 3 3 3 3 3 15 15 15 725 1 1 1 1 1 1 1 1 1 5 5 5 5 5 5 5 5 5 761 5 5 5 5 5 5 5 5 5 727 727 3 5 66 66 66 66 5 5 5 5 5 5 5 5 5 721 1 1 1 1 1 1 1 1 1 4 4 4 4 4 4 4 4 4 758 338 2 4 4 4 4 4 4 4 4 4 770 2 2 2 2 2 2 2 2 2 4 4 4 4 4 4 4 4 4 42 742 742 404 3 3 3 3 3 3 3 3 3 746 4 4 4 1 1 1 1 1 1 4 4 4 4 4 4 1 1 1 5 2 2 2 2 2 2 2 2 2 4 1 1 1 1 1 1 1 1 1 2 728 753 4 4 4 4 4 4 4 4 4 772 4 729 4 4 4 4 4 4 4 4 4 724 5 5 5 5 5 5 5 5 5 737 53 743 4 4 4 4 4 4 4 4 4 5 5 5 5 5 5 5 5 5 740 723 747 747 3 3 3 3 3 3 3 3 3 735 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 754 726 193 193 193 5 5 5 4 4 4 4 4 4 5 5 5 5 5 5 4 4 4 739 739 280 760 5 5 5 5 5 5 5 5 5 741 2 764 764 730 1 1 1 1 1 1 1 1 1 5 731 494