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21 July, 2011 Oral poster discussion session, 6th IAS Conference, Roma

Causes of death and risk factors of mortality in HIV-infected patients treated for tuberculosis enrolled in the CAMELIA trial (ANRS 1295/12160 – CIPRA KH001/10425).

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21 July, 2011 Oral poster discussion session, 6th IAS Conference, Roma

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  1. Causes of death and risk factors of mortality in HIV-infected patients treated for tuberculosis enrolled in the CAMELIA trial (ANRS 1295/12160 – CIPRA KH001/10425) O. Marcy, D. Laureillard, S. Chan, Y. Madec, C. Mayaud, L. Borand, N. Prak, C. Kim, K.K. Lak, C. Hak, B. Dim, T. Sok, A.E. Goldfeld and F.X. Blanc 21 July, 2011 Oral poster discussion session, 6th IAS Conference, Roma

  2. Study design • HIV+ patients with AFB+ tuberculosis (TB) and CD4 ≤ 200/mm3 • TB regimen: 2RHEZ/4RH • Randomized to start ART (D4T/3TC/EFV) • Early: 2 weeks after TB treatment onset • Late: 8 weeks after TB treatment onset • Primary endpoint: survival • Causes of death were secondarily assessed ANRS 1295/12160 – CIPRA KH001/10425 study

  3. Mortality • Median follow-up duration: 25 months • 149 / 661 (22%) enrolled patients died • Place of death: • 63 (42%) deaths occurred at home • 86 (58%) occurred in hospital ANRS 1295/12160 – CIPRA KH001/10425 study

  4. Causes of death ANRS 1295/12160 – CIPRA KH001/10425 study

  5. Risk factors of mortality

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